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 详细处方信息以本药内容附件PDF文件（201211017584937.pdf）的“原文Priscribing Information”为准
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部分中文甲泼尼龙处方资料（仅供参考）

甲泼尼龙Methylprednisolone
【其它名称】：甲基去氢氢化可的松、6α-甲基氢化泼尼松、甲基泼尼松、去甲泼尼龙、甲基氢化泼尼松、甲强龙、甲氢泼尼松、美卓乐、舒禄-美卓乐、Dimedrol、Medrol、Medron、Urbason、Bioprednon、Methylprednisolonum

【适应证】 抗炎作用较强，对钠潴留作用微弱，作用同泼尼松。 1.甲基氢化泼尼松醋酸酯混悬剂分解缓慢，作用持久，可供肌内、关节腔内注射。 2.甲基氢化泼尼松琥珀酸钠为水溶性，可供肌注，或溶于葡萄糖液中静脉滴注。因半衰期短，故治疗严重休克时，应于４小时后重复给药。参见泼尼松龙。适用于危重型系统性红斑狼疮（狼疮脑病、血小板显著低下、肾炎、心肌损害）、重症多肌炎、皮肌炎及血管炎、哮喘发作。器官移植术前后。

【给药说明】
　　1.本品4mg的抗炎活性相当于5mg泼尼松龙。
　　2.在某些急症治疗中，通常采用肌内注射或静脉给药，以期快速起效。
　　3.甲泼尼龙醋酸酯因分解缓慢，作用较持久，因此用于肌内注射可达到较持久的全身效应。
　　4.急性脊髓损伤的治疗应在创伤后8小时内开始。
　　5. 因为此药半衰期只有30分钟，故治疗严重休克时，应于4小时后重复给药。
　　6.注射液在荧光或紫外线下易分解破坏。
　　7.本药滁钠作用较弱，故一般不用作肾上腺皮质功能减退的替代治疗。若需使用，则需与盐皮质激素合用。
　　8.其余参见泼尼松龙。

【用量用法】
1.口服：开始１日１６～２４ｍｇ，分２次服，维持量１日４～８ｍｇ。
2.关节腔内及肌内注射：１次１０～８０ｍｇ。

【注重事项】针剂在紫外线和荧光下易分解破坏，故应避光，其他注重事项同泼尼松。

【药品规格】
1.片剂：每片２ｍｇ、４ｍｇ。
2.甲基氢化泼尼松混悬液：每支２０ｍｇ（１ｍｌ）、４０ｍｇ（１ｍｌ）。

【禁用】
　　严重的精神病史，活动性胃、十二指肠溃疡，新近胃肠吻合术后，较重的骨质疏松，明显的糖尿病，严重的高血压，未能用抗菌药物控制的病毒、细菌、霉菌感染。

【慎用】
　　心脏病或急性心力衰竭、糖尿病、憩室炎、情绪不稳定和有精神病倾向、全身性真菌感染、青光眼、肝功能损害、眼单纯性疱疹、高脂蛋白血症、高血压、甲状腺功能减退症（此时糖皮质激素作用增强）、重症肌无力、骨质疏松、胃溃疡、胃炎或食管炎、肾功能损害或结石、结核病等。

【不良反应】
　　1．体液及电解质紊乱：钠潴留、某些敏感患者的充血性心力衰竭、高血压、体液潴留、钾离子丧失及低钾性碱中毒。
　　2．肌肉骨骼系统：类固醇性肌病、肌无力、骨质巯松、病理性骨折、压迫性椎骨骨折及无菌性坏死。
　　3．胃肠道：可能穿孔或出血的消化道溃疡、消化道出血、胰腺炎、食道炎及肠穿孔。
　　4．皮肤病：妨碍伤口愈合、瘀点和瘀斑及皮肤脆薄。
　　5．代谢：因蛋白质分解造成的负氮平衡。
　　6．神经病：颅内压升高、假性脑肿瘤、精神错乱及癫痫发作。
　　7．内分泌：月经失调、引发柯兴氏症、抑制垂体－肾上腺皮质轴、糖耐量降低、引发潜在的糖尿病、增加糖尿病患者对胰岛素和口服降糖药的需求及抑制儿童生长。
　　8．眼：后方囊下白内障、眼内压增高及眼球突出。
　　9．免疫系统：掩盖感染、潜在感染发作、机会性感染、过敏反应及可能抑制皮试反应。

Brand Name
Depo-Medrol

Pronunciation
DEPP-o-MED-rawl

Common Drug Name
Methylprednisolone

What should I discuss with my veterinarian while considering Depo-Medrol?
Ask your veterinarian what dose will provide the most benefit while minimizing any side effects. Also discuss how long the treatment period will be and what type of outcome is expected. You and your veterinarian should talk about any other treatment options that are recommended for your pet.

Tell your veterinarian if your pet has diabetes; stomach ulcers; Cushings disease; a bacterial, viral or fungal infection; heart, liver or kidney disease; may be pregnant; or is nursing.

Notify your veterinarian of any other medications or supplements your dog is taking, and also if your dog has had any reactions to previous medications.

What should I do if I miss a dose?
Contact your veterinarian to determine when to give the next dose.

What is the most important information I should know?
You will need to work closely with your veterinarian to determine the proper dose. If used long-term, this medication should not be stopped abruptly. The dose needs to be tapered over a course of time as determined by your veterinarian.

Who should not take it?
Not for use in animals with systemic fungal infections, some types of mange (mites), stomach ulcers, Cushing's disease, high blood pressure, kidney disease, or congestive heart failure. Do not use in pregnant animals. It may cause premature birth and birth defects in some animals. Depo-Medrol may stunt growth if used in young, growing animals or is given to nursing mothers.

What side effects may be seen when taking Depo-Medrol?
Side effects are usually dose dependent. If side effects occur, contact your veterinarian, who may decrease the dosage, frequency, or type of corticosteroid.

The most common side effects are increased appetite, drinking, and urination. Your pet may have more "accidents" and need to go outside or use the litter box more often. Less common side effects include weight gain, panting, diarrhea, vomiting, and behavior changes.

Side effects of daily long-term use include muscle loss, weakness, and the development of diabetes or hyperadrenocorticism (Cushing's disease). The typical signs of these diseases are increased thirst, urination, and appetite. Animals with Cushing's disease may also develop thin skin, a poor hair coat, and a "pot-belly." Side effects may also include activation or worsening of hypothyroidism or pancreatitis.

Immune system suppression may occur at high doses, making a pet more susceptible to infection. Contact your veterinarian if your pet has a fever (over 103° F), painful urination (a sign of urinary tract infection), tiredness, sneezing, coughing, or runny eyes.

How is it stored?
Store at room temperature, in tight, light resistant, childproof container. Do not freeze.

What should I do if I know of or suspect there has been an overdose?
Chronic, or long-term, overdose is likely to cause signs of Cushing's disease or diabetes mellitus; both diseases commonly cause increased urinating, drinking, and eating. Abruptly stopping long-term treatment may cause signs of Addison's disease, including vomiting, weakness, collapse and sudden death. If you know or suspect your pet has had an overdose, or if you observe any of these signs in your pet, contact your veterinarian immediately.

What should I avoid when giving my pet Depo-Medrol?
Consult your veterinarian before using Depo-Medrol with vitamins and supplements or non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, carprofen (Novox or Rimadyl), deracoxib (Deramaxx), etodolac (EtoGesic), meloxicam (Metacam),firocoxib (Previcox), or tepoxalin (Zubrin). Discuss the use of Depo-Medrol® with your veterinarian if it will be used along with insulin, modified live vaccines, phenytoin, phenobarbital, rifampin, cyclosporine, estrogens, erythromycin, or mitotane, amphotericin B, furosemide, or thiazide, since interactions may occur.

Depo-Medrol may cause abnormal levels of hepatic enzymes, thyroid hormone, cholesterol, and potassium in the blood, and can affect many laboratory tests. Make sure your veterinarian knows your pet is taking Depo-Medrol prior to any testing.

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 详细处方信息以本药内容附件PDF文件（201211017584937.pdf）的“原文Priscribing Information”为准
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