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  药店国别: 美国药房
产地国家: 美国
所属类别: 心血管系统药物->降胆固醇
处方药:处方药
包装规格: 10;10毫克/片 40片/盒
计价单位:
   
生产厂家中文参考译名:
默克
生产厂家英文名:
Merck
该药品相关信息网址1:
http://www.liptruzet.com/
该药品相关信息网址2:
http://www.webmd.com/drugs/drug-164179-Liptruzet+Oral.aspx?drugid=164179&drugname=Liptruzet+Oral
原产地英文商品名:
Liptruzet 10mg; 10mg 40 Tablets (Minimum order qty: 2)
原产地英文药品名:
EZETIMIBE; ATORVASTATIN
中文参考商品译名:
Liptruzet 10;10毫克/片 40片/盒 (最低订货量:2)
中文参考药品译名:
依折麦布和阿托伐他汀
原产地国家批准上市年份:
0000/00/00
英文适应病症1:
High Cholesterol
临床试验期:
完成
中文适应病症参考翻译1:
高胆固醇
药品信息:
2013年5月3日,默克公司宣布美国食品与药品管理局(FDA)已批准Liptruzet(依折麦布和阿托伐他汀)用于单纯饮食治疗未能控制低密度脂蛋白胆固醇(LDL-C)水平达标的原发性或混合性高脂血症患者。该药物将作为饮食治疗的辅助,用于降低LDL-C水平。这一药物的适应证还包括降低总胆固醇、载脂蛋白B、甘油三酯和非高密度脂蛋白胆固醇水平,以及升高高密度脂蛋白胆固醇水平。尚不明确Liptruzet对心血管发病率和病死率的影响是否大于阿托伐他汀。 每日1次Liptruzet通过抑制胆固醇在消化道的吸收(通过依折麦布)和胆固醇在肝脏的产生(通过阿托伐他汀)而双管齐下。每片Liptruzet片剂含依折麦布10 mg和阿托伐他汀10、20、40或80 mg。 在一项多中心、双盲、安慰剂对照的临床试验中,628例高脂血症患者接受最长达12周的治疗,结果显示最小剂量(10/10 mg)Liptruzet治疗使LDL-C降低了53%(平均基线LDL-C为177 mg/dl),10/20 mg剂量的Liptruzet使LDL-C降低54%(平均基线LDL-C为184 mg/dl),10/40 mg剂量的Liptruzet使LDL-C降低56%(平均基线LDL-C为184 mg/dl),最大剂量(10/80 mg) Liptruzet使LDL-C降低61%(平均基线LDL-C为183 mg/dl)。来自其他研究的数据显示,Liptruzet降低LDL-C水平的效果优于单用阿托伐他汀。 在一项关于Liptruzet的临床试验中,报告的最常见不良反应(无论原因如何)包括丙氨酸氨基转移酶水平升高、天冬氨酸氨基转移酶水平升高和肌肉骨骼疼痛。因此,应避免对有活动性肝病或无法解释的持续性肝脏转氨酶升高患者处方Liptruzet。Liptruzet说明书中也包含关于发生肌病和横纹肌溶解的警告和指导。 建议的Liptruzet起始剂量为10/10 mg或 10/20 mg每日1次,对于需要更大幅度降低LDL-C的患者,也可给予10/40 mg每日1次。该药可在一天中的任何时间使用,不受进餐时间影响。 This combination medication is used along with a proper diet to help lower "bad" cholesterol and fats (such as LDL, triglycerides) and raise "good" cholesterol (HDL) in the blood. Ezetimibe works by reducing the amount of cholesterol your body absorbs from your diet. Atorvastatin belongs to a group of drugs known as "statins." It works by reducing the amount of cholesterol made by the liver. In addition to eating a proper diet (such as a low-cholesterol/low-fat diet), other lifestyle changes that may help this medication work better include exercising, losing weight if overweight, and stopping smoking. Consult your doctor for more details. Lowering "bad" cholesterol and triglycerides and raising "good" cholesterol decreases the risk of heart disease and helps prevent strokes and heart attacks. How to use Liptruzet oral Read the Patient Information Leaflet if available from your pharmacist before you start taking this product and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth with or without food as directed by your doctor, usually once daily. The manufacturer directs not to split/crush the tablet before taking it. However, many similar drugs (immediate-release tablets) can be split/crushed. Follow your doctor's directions on how to take this medication. The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Do not increase your dose or use this drug more often than prescribed. Your condition will not improve any faster, and your risk of side effects will increase. Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. Grapefruit can increase the chance of side effects with this medicine. Ask your doctor or pharmacist for more details. If you are taking a bile acid sequestrant (such as cholestyramine or colestipol), take this product at least 2 hours before or at least 4 hours after taking the bile acid sequestrant. These medications may bind to ezetimibe/atorvastatin, preventing your body from fully absorbing the drug. Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. It is important to continue taking this medication even
更新日期: 2014-11-11
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