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 详细处方信息以本药内容附件PDF文件（2014102622280226.pdf）的“原文Priscribing Information”为准
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部分中文INFUVITE  PEDIATRIC处方资料（仅供参考）

    小儿多种维生素，本品是同时含有9种水溶性维生素和4种脂溶性维生素的多种维生素注射液，注射液已经在国外上市多年。临床应用明显优于目前国内市场上销售的注射用12种复合维生素、注射用水溶性维生素、注射用脂溶性维生素(I)、注射用脂溶性维生素(II)和复方维生素注射(4)等复合维生素针剂品种。

Ø 中文名称：小儿多种维生素注射液

Ø 处方组成：本品每瓶中同时含有9种水溶性维生素和4种脂溶性维生素

Ø 商品名为：INFUVITE  PEDIATRIC

Ø 用法用量：必须稀释后进行静脉输注。直接加入到500ml的输液中，最好是1000ml。配伍溶液可是：葡萄糖、氯化钠等相关输液中。将成人多种维生素注射液（13）加入到静脉注射用液体中之后，适宜立即使用。

Ø 适应症：本品适应于接受胃肠外营养多种维生素每日所需剂量以及在其他情形下静脉常规需要量，包括外科手术、广泛烧伤、骨折和其他外伤，严重感染性疾病和昏迷。可用于连续发生的严重营养状态改变下机体新陈代谢的应激反应和组织营养缺乏的情况。

Ø特点： 目前最全的同时含有脂溶性维生素与水溶性维生素注射用剂型（含有维生素K1）；

药理学：
一般药理试验
1.对中枢神经系统的影响
1)对犬自主行为的影响
    10例比格犬(2/组) 采用隐静脉注射给药新配制的CernivitTM-12或加热分解的CernivitTM-12混合微胶粒，给药容量为0.1、0.3和1ml/kg，给药速度为5ml/min。比格犬再次给药的时间间隔为4周。动物给药后观察自主行为的变化。
    比格犬上述给药容量未见自主行为的异常变化。1例比格犬新配制的CernivitTM-12以1ml/kg静脉注射期间唾液分泌过多，未见一般症状的异常变化。
2)对小鼠戊四氮诱发痉挛或最大电休克痉挛的影响
    雌性小鼠静脉注射给药新配制的CernivitTM-12或加热分解的CernivitTM-12混合微胶粒和丙二醇，给药容量为0.1、0.3、1.O和3.0ml/kg，对电休克(50Hz 10mA达0.2sec)或戊四氮(120mg/kg IP)诱导的强直性痉挛均无影响。
2.对心血管系统的影响
1)新配制的CernivitTM-12或加热分解的CernivitTM-12混合微胶粒对清醒血压正常的犬收缩期血压、心率和自主行为的影响
    8例雌性杂种犬分组，每组为4只采用静脉注射给药新配制的CernivitTM-12或加热分解的CernivitTM-12混合微胶粒，给药容量为0.01、0.03、0.1和0.3ml/kg。比格犬再次给药的时间间隔为4周。动物给药后观察自主行为的变化。
犬静脉注射给药后，血压轻度和非持续性血压下降，0.3ml/kg剂量组给药后60min达最大效应为8mmHg。最高剂量组给药后心率增加，最大效应心率增加为18次/min。上述效应持续5-10min。部分陈旧CernivitTM-12混合微胶粒，犬收缩期血压、心率和自主行为未见异常的变化。本品口服吸收后，经门静脉到达肝脏，然后进入肝细胞，在细胞内转换成活性三磷酸盐。本品的5’三磷酸化合物低浓度时，能竞争性地抑制D-HBV编码的DNA聚合酶，结合到新合成的HBV DNA中，这种结合使DNA链的延长终止，从而抑制病毒DNA的复制。

适应症：
    本品适用于成人接受胃肠外营养多种维生素每日所需剂量以及在其他情形下静脉常规需要量，包括外科手术、广泛烧伤、骨折和其他外伤，严重感染性疾病和昏迷。可用于连续发生的严重营养状态改变下机体新陈代谢的应激反应和组织营养缺乏的情况。

不良反应：
    很少有采用胃肠外多种维生素治疗后产生过敏反应报告。也很少有采用大剂量静脉输入维生素B1后发生过敏反应的报告。维生素B1与其他的B族维生素合用时，其过敏反应是可以忽略的。没有使用多种维生素注射制剂产生致命过敏反应的报告。

保存：需要在2－8℃保存。

Infuvite Pediatric - General Information:
Infuvite Pediatric (commonly known as Vitamin B12) is the most chemically complex of all the vitamins. Infuvite Pediatric's structure is based on a corrin ring, which, although similar to the porphyrin ring found in heme, chlorophyll, and cytochrome, has two of the pyrrole rings directly bonded. The central metal ion is Co (cobalt). Infuvite Pediatric cannot be made by plants or by animals, as the only type of organisms that have the enzymes required for the synthesis of cyanocobalamin are bacteria and archaea. Higher plants do not concentrate cyanocobalamin from the soil and so are a poor source of the substance as compared with animal tissues. Infuvite Pediatric is naturally found in foods including meat (especially liver and shellfish), eggs, and milk products. [HMDB]

Pharmacology:
Infuvite Pediatric (Vitamin B12) is a water-soluble organometallic compound with a trivalent cobalt ion bound inside a corrin ring. It is needed for nerve cells and red blood cells, and to make DNA. Vitamin B12 deficiency is the cause of several forms of anemia.

Infuvite Pediatric for patients
Patients with pernicious anemia should be informed that they will require monthly injections of vitamin B12 for the remainder of their lives. Failure to do so will result in return of the anemia and in development of incapacitating and irreversible damage to the nerves of the spinal cord. Also, patients should be warned about the danger of taking folic acid in place of vitamin B12, because the former may prevent anemia but allow progression of subacute combined degeneration.

A vegetarian diet which contains no animal products (including milk products or eggs) does not supply any vitamin B12. Patients following such a diet, should be advised to take oral vitamin B12 regularly. The need for vitamin B12 is increased by pregnancy and lactation. Deficiency has been recognized in infants of vegetarian mothers who were breast fed, even though the mothers had no symptoms of deficiency at the time.

Infuvite Pediatric Interactions
Persons taking most antibiotics, methotrexate and pyrimethamine invalidate folic acid and vitamin B12 diagnostic blood assays. Colchicine para-aminosalicylic acid and heavy alcohol intake for longer than 2 weeks may produce malabsorption of vitamin B12.

Infuvite Pediatric Contraindications
Hemochromatosis and hemosiderosis are contraindications to iron therapy.

Additional information about Infuvite Pediatric
Infuvite Pediatric Indication: For treatment of pernicious anemia (due to lack of or inhibition of intrinsic factor) and for prevention and treatment of vitamin B 12 deficiency.
Mechanism Of Action: Vitamin B12 is used in the body in two forms: Methylcobalamin and 5-deoxyadenosyl cobalamin. The enzyme methionine synthase needs methylcobalamin as a cofactor. This enzyme is involved in the conversion of the amino acid homocysteine into methionine. Methionine in turn is required for DNA methylation. 5-Deoxyadenosyl cobalamin is a cofactor needed by the enzyme that converts L-methylmalonyl-CoA to succinyl-CoA. This conversion is an important step in the extraction of energy from proteins and fats. Furthermore, succinyl CoA is necessary for the production of hemoglobin, the substances that carries oxygen in red blood cells.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Cyanocobalamin
Synonyms: Vitamin B12; Vitamin B12 complex; Cyanocob(III)alamin
Drug Category: Antianemic Agents; Essential Vitamin; Vitamins (Vitamin B Complex)
Drug Type: Small Molecule; Nutraceutical; Approved
Other Brand Names containing Cyanocobalamin: Cyomin; Dicopac; Nascobal; Rubramin PC; Anacobin; Bedoz; Berocca PN; Berubigen; Betalin 12; Cernevit-12; Cobavite; Cobex; Cobolin-M; Crystamine; Crysti-12; Cyanocobalamin Co 57 Schilling Test Kit; Cyanoject; Depinar; Dicopac Kit; Infuvite Pediatric; M.V.I. Pediatric; Neuroforte-R; Primabalt; Redisol; Rubivite; Rubratope-57 Kit; Rubratope-60 Kit; Ruvite; Shovite; Vi-Twel; Vibal; Vibisone; Vitabee 12; Vitaped;
Absorption: Readily absorbed in the lower half of the ileum.
Toxicity (Overdose): Anaphylactic reaction (skin rash, itching, wheezing)-after parenteral administration. ORL-MUS LD50 > 8000 mg/kg
Protein Binding: Very high (to specific plasma proteins called transcobalamins); binding of hydroxocobalamin is slightly higher than cyanocobalamin.
Biotransformation: Hepatic
Half Life: Approximately 6 days (400 days in the liver).
Dosage Forms of Infuvite Pediatric: Liquid Intramuscular
Solution Intramuscular
Capsule Oral
Powder Oral
Liquid Oral
Tablet Oral
Tablet, extended release Oral
Chemical IUPAC Name: Not Available
Chemical Formula: C63H89CoN14O14P+
Organisms Affected: Humans and other mammals

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 详细处方信息以本药内容附件PDF文件（2014102622280226.pdf）的“原文Priscribing Information”为准
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