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当前本网站药物产品种数共 8524 处方药 8148 非处方药 269 保健品/医疗用具 107

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  药店国别: 美国药房
产地国家: 美国
所属类别: 作用于消化系统药物->抗酸及治疗溃疡病药物
处方药:处方药
包装规格: 150毫克/片 65片/盒
计价单位:
  点击放大  
生产厂家中文参考译名:
勃林格殷格翰
生产厂家英文名:
Boehringer Ingleheim
该药品相关信息网址1:
http://www.drugs.com/omeprazole.html
该药品相关信息网址2:
http://en.wikipedia.org/wiki/Omeprazole
原产地英文商品名:
ZANTAC OTC 150 MG 65 TABLETS
原产地英文药品名:
OMEPRAZOLE
原产地英文化合物名称:
5-Methoxy-2-(4-methoxy-3,5-dimethyl-2-pyridinylmethylsulfinyl)-1H-benzimidazole
中文参考商品译名:
善胃得 OTC 150毫克/片 65片/盒
中文参考药品译名:
奥美拉唑
中文参考化合物名称:
5-甲氧基石-[(4-甲氧基-3,5-二甲基-2-吡啶基)-甲基]亚磺酰-1H-苯骈咪唑
原产地国家批准上市年份:
0000/00/00
英文适应病症1:
Gastric ulcer
英文适应病症2:
Duodenal ulcer
英文适应病症3:
Stress ulcer
英文适应病症4:
Reflux esophagitis
英文适应病症5:
Zhuo - Ellison syndrome
临床试验期:
完成
中文适应病症参考翻译1:
胃溃疡
中文适应病症参考翻译2:
十二指肠溃疡
中文适应病症参考翻译3:
应激性溃疡
中文适应病症参考翻译4:
反流性食管炎
中文适应病症参考翻译5:
卓-艾综合征
药品信息:

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 详细处方信息以本药内容附件PDF文件(2010122800481223.pdf)的“原文Priscribing Information”为准
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部分中文奥美拉唑处方资料(仅供参考)

【品名】奥美拉唑 Omeprazole

【化学名称】5-甲氧基石-[(4-甲氧基-3,5-二甲基-2-吡啶基)-甲基]亚磺酰-1H-苯骈咪唑
5-Methoxy-2-(4-methoxy-3,5-dimethyl-2-pyridinylmethylsulfinyl)-1H-benzimidazole

【主要用途】本品对消化性胃溃疡确有良好疗效,具有高效低毒,治愈率高,治愈时间短,耐受性好,病人易于接受等优点。该品属于质子泵抑制剂类,可直接作用于酸泵,抑制其分泌胃酸,并且对HP有杀灭作用。

【药品类别】抗酸及抗溃疡药

【适用症】
奥美拉唑胶囊适用于胃溃疡、十二指肠溃疡、应激性溃疡、反流性食管炎和卓-艾综合征(胃泌素瘤)。

【注意事项】
(1)治疗胃溃疡时,应首先排除溃疡型胃癌的可能,因用奥美拉唑胶囊治疗可减轻其症状, 从而延误治疗。
(2)肝肾功能不全者慎用。
(3)奥美拉唑胶囊为肠溶胶囊,服用时注意不要嚼碎,以免药物在胃内过早释放而影响疗效。

【用法与用量】
口服,不可咀嚼。
(1) 消化性溃疡:一次20mg(一次1片),一日1~2次。每日晨起吞服或早晚各一次,胃溃疡疗程通常为4~8周,十二指肠溃疡疗程通常2~4周。
(2) 反流性食管炎:一次20~60 mg(一次1~3片),一日1~2次。晨起吞服或早晚各一次,疗程通常为4~8周。
(3) 卓-艾综合征:一次60mg(一次3粒),一日1次,以后每日总剂量可根据病情调整为20~120mg(1~6粒),若一日总剂量需超过80mg(4粒)时,应分为两次服用。

【禁忌症】
对奥美拉唑胶囊过敏者、严重肾功能不全者及婴幼儿禁用。

【儿童用药注意事项】
尚无儿童用药经验,婴幼儿禁用。

【孕妇、哺乳期妇女用药注意事项】
虽然动物实验表明,奥美拉唑胶囊无胎儿毒性或致畸作用,但对孕妇一般不用,对哺乳期妇女也应慎用。

【不良反应】
奥美拉唑胶囊耐受性良好,常见不良反应是腹泻、头痛、恶心、腹痛、胃肠胀气及便秘,偶见血清氨基转移酶(ALT,AST)增高、皮疹、眩晕、嗜睡、失眠等,这些不良反应通常是轻微的,可自动消失,与剂量无关。长期治疗未见严重的不良反应,但在有些病例中可发生胃粘膜细胞增生和萎缩性胃炎。

【药物相互作用】
奥美拉唑胶囊可延缓经肝脏代谢药物在体内的消除,如安定、苯妥英钠、华法令、硝苯啶等,当奥美拉唑胶囊和上述药物一起使用时,应减少后者的用量。

【药理】
质子泵抑制剂。奥美拉唑胶囊为脂溶性弱碱性药物,易浓集于酸性环境中,因此口服后可特异地分布于胃黏膜壁细胞的分泌小管中,并在此高酸环境下转化为亚磺酰胺的活性形式,然后通过二硫键与壁细胞分泌膜中的H+,K+-ATP酶(又称质子泵)的巯基呈不可逆性的结合,生成亚磺酰胺与质子泵的复合物,从而抑制该酶活性,阻断胃酸分泌的最后步骤,因此奥美拉唑胶囊对各种原因引起的胃酸分泌具有强而持久的抑制作用。

【药物代谢动力学】
口服奥美拉唑胶囊后,经小肠吸收,1小时内起效,0.5~3.5小时血药浓度达峰值,作用持续24小时以上,可分布到肝、肾、胃、十二指肠、甲状腺等组织,且易透过胎盘。通常单剂量生物利用度约35%,多剂量生物利用度增至约60%,血浆蛋白结合率为95%~96%,血浆半衰期为0.5~1小时,慢性肝病患者为3小时。
奥美拉唑胶囊在体内经肝脏微粒体细胞色素P450氧化酶系统代谢,代谢物的约80%经尿排泄,其余由胆汁分泌后从粪便排泄。

【包装规格】20mg。

【贮藏】密封,在阴凉干燥处保存。

What is omeprazole?
Omeprazole belongs to a group of drugs called proton pump inhibitors. Omeprazole decreases the amount of acid produced in the stomach.

Omeprazole is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions caused by excess stomach acid. It is also used to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid).

Omeprazole may also be given together with antibiotics to treat gastric ulcer caused by infection with helicobacter pylori (H. pylori).

Omeprazole is not for immediate relief of heartburn symptoms.

Omeprazole may also be used for other purposes not listed in this medication guide.

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Important information about omeprazole
Omeprazole is not for immediate relief of heartburn symptoms.

Some conditions are treated with a combination of omeprazole and antibiotics. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice.

You should not take this medication if you are allergic to omeprazole or to any other benzimidazole medication such as albendazole (Albenza), or mebendazole (Vermox).

Take omeprazole for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared.

Prilosec OTC (over-the-counter) should be taken only once every 24 hours for 14 days. It may take up to 4 days for full effect. Do not take more than one tablet every 24 hours.

Allow at least 4 months to pass before you start another 14-day treatment with Prilosec OTC. Call your doctor if you have additional symptoms and need treatment before the 4 months has passed.

Heartburn is often confused with the first symptoms of a heart attack. Seek emergency medical attention if you have chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, and a general ill feeling.

Ask a doctor or pharmacist if it is safe for you to take omeprazole if you have liver disease or heart disease. You may need a dose adjustment or special tests.

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Before taking omeprazole
You should not take this medication if you are allergic to omeprazole or to any other benzimidazole medication such as albendazole (Albenza), or mebendazole (Vermox).

Ask a doctor or pharmacist if it is safe for you to take omeprazole if you have liver disease or heart disease. You may need a dose adjustment or special tests.

Do not use over-the-counter omeprazole (Prilosec OTC) without the advice of a doctor if you have:
trouble or pain with swallowing;
bloody or black stools;
vomit that looks like blood or coffee grounds;
heartburn that has lasted for over 3 months;
frequent chest pain;
heartburn with wheezing;
unexplained weight loss;
nausea or vomiting; or
stomach pain.

Some conditions are treated with a combination of omeprazole and antibiotics. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice.

Taking a proton pump inhibitor such as omeprazole may increase your risk of bone fracture in the hip, wrist, or spine. This effect has occurred mostly in people who have taken the medication long term or at high doses, and in those who are age 50 and older. It is not clear whether omeprazole is the actual cause of an increased risk of fracture. Before you take this medication, tell your doctor if you have osteoporosis or osteopenia (low bone mineral density).

FDA pregnancy category C. It is not known whether omeprazole will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Omeprazole can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are taking omeprazole. Do not give this medication to a child younger than 16 years old without the advice of a doctor.

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How should I take omeprazole?
Take omeprazole exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Omeprazole is usually taken before eating. Follow your doctor's instructions.

Do not crush, chew, or break an enteric-coated omeprazole tablet. Swallow the pill whole. The enteric-coated pill has a special coating to protect your stomach. Breaking the pill could damage this coating.

You may open the omeprazole delayed-release capsule and sprinkle the medicine into a spoonful of applesauce to make swallowing easier. Swallow this mixture right away without chewing. Do not save the mixture for later use. Discard the empty capsule.

Dissolve the powder in a small amount of water. Use 1 teaspoon of water for the 2.5-mg packet, or 1 Tablespoon of water for the 10-mg packet. Let the mixture stand for 2 or 3 minutes, then stir and drink right away. To make sure you get the entire dose, add a little more water to the same glass, swirl gently and drink right away.

Prilosec OTC (over-the-counter) should be taken only once every 24 hours for 14 days. Take the medicine in the morning before you eat breakfast. It may take up to 4 days for full effect. Do not take more than one tablet every 24 hours.

Allow at least 4 months to pass before you start another 14-day treatment with Prilosec OTC. Call your doctor if you have additional symptoms and need treatment before the 4 months has passed.

Do not crush, chew, or break a Prilosec OTC tablet. Swallow the pill whole. Take omeprazole for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Call your doctor if your symptoms do not improve or if they get worse while you are taking this medicine.

Store omeprazole at room temperature away from moisture and heat.

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What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

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What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include drowsiness, blurred vision, fast heartbeat, nausea, vomiting, sweating, headache, or dry mouth.

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What should I avoid while taking omeprazole?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.

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Omeprazole side effects
Get emergency medical help if you have any of these signs of an allergic reaction to omeprazole: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious omeprazole side effects may include:
stomach pain, gas;
nausea, vomiting, diarrhea; or
headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Omeprazole Dosing Information
Usual Adult Omeprazole Dose for Duodenal Ulcer:
20 mg orally once a day before a meal. Most patients heal within 4 to 8 weeks.

Usual Adult Omeprazole Dose for Helicobacter pylori Infection:
Dual therapy: omeprazole 40 mg orally once a day in the morning plus clarithromycin 500 mg orally 3 times a day on days 1 to 14. Beginning on day 15, omeprazole 20 mg orally once a day in the morning on days 15 to 28.
Triple therapy: omeprazole 20 mg plus clarithromycin 500 mg plus amoxicillin 1000 mg all given orally twice a day for 10 days. If an ulcer is present at the initiation of therapy, continue omeprazole 20 mg orally once a day for an additional 18 days.
Study (n=294) - Canadian Adult Dyspepsia Empiric Treatment-Helicobacter pylori positive (CADET-Hp): omeprazole 20 mg, metronidazole 500 mg, and clarithromycin 500 mg, twice daily for 7 days.

Usual Adult Omeprazole Dose for Gastric Ulcer:
40 mg orally once a day before a meal for 4 to 8 weeks.

Usual Adult Omeprazole Dose for Erosive Esophagitis:
20 mg orally once a day before a meal. This dosage may be increased to 40 mg per day based on desired clinical response and patient tolerance. Studies have been completed up to 12 months for maintenance therapy of erosive esophagitis.

Usual Adult Dose for Zollinger-Ellison Syndrome:
Initial: 60 mg orally once a day. Dosage should be individualized to patient's needs.
Maintenance: doses up to 120 mg 3 times a day have been administered. Daily doses greater than 80 mg should be divided.

Usual Adult Dose for Gastroesophageal Reflux Disease:
Initial: 20 mg orally once a day before a meal for 4 to 8 weeks. This dosage may be increased to 40 mg per day if needed.
Maintenance: long-term treatment with doses of 10 to 20 mg per day may be required for maintenance therapy of refractory disease and appears to be safe.

Usual Adult Dose for Multiple Endocrine Adenomas:
Initial: 60 mg orally once a day before a meal. This dosage may be titrated based on desired clinical response and patient tolerance.
Maintenance: doses up to 120 mg 3 times a day have been administered. Daily doses greater than 80 mg should be divided.

Usual Adult Dose for Systemic Mastocytosis:
Initial: 60 mg orally once a day before a meal. This dosage may be titrated based on desired clinical response and patient tolerance.
Maintenance: doses up to 120 mg 3 times a day have been administered. Daily doses greater than 80 mg should be divided.

Usual Adult Dose for Dyspepsia:
Prevention of frequent heartburn: 20 mg orally once daily, before a meal, for 14 days.
Usual Pediatric Omeprazole Dose for Gastroesophageal Reflux Disease:
>2 years
<20 kg: 10 mg once a day.
>=20 kg: 20 mg once a day
Studies:
>1 year: 0.7 to 3.5 mg/kg/day, given in 2 divided doses, not to exceed 80 mg daily.
Study (n=115)
<1 year: 1 to 1.5 mg/kg once daily for 56 days. Omeprazole was administered orally as a 2 mg/mL bicarbonate suspension.

Usual Pediatric Omeprazole Dose for Erosive Esophagitis:
>1 years: 0.7 to 3.5 mg/kg/day (maximum 80 mg/day), for 3 months. Dosage increments of 0.7 mg/kg/day to achieve stomach pH of <4.

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What other drugs will affect omeprazole?
Tell your doctor about all other medicines you use, especially:
a blood thinner such as warfarin (Coumadin);
cilostazol (Pletal);
clopidogrel (Plavix);
diazepam (Valium);
disulfiram (Antabuse);
cyclosporine (Gengraf, Neoral, Sandimmune);
tacrolimus (Prograf);
phenytoin (Dilantin);
ketoconazole (Extina, Ketozole, Nizoral, Xolegal), voriconazole (Vfend);
ampicillin (Omnipen, Principen);
HIV or AIDS medications such as atazanavir (Reyataz), nelfinavir (Viracept), saquinavir (Invirase); or
iron (Feosol, Mol-Iron, Fergon, Femiron, others).

This list is not complete and other drugs may interact with omeprazole. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

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 详细处方信息以本药内容附件PDF文件(2010122800481223.pdf)的“原文Priscribing Information”为准
---------------------------------------------------------------

2010-12-28更新

更新日期: 2014-09-28
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