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  药店国别: 日本药房
产地国家: 日本
所属类别: 心血管系统药物->抗心绞痛药物
处方药:处方药
包装规格: 12毫克 10瓶
计价单位:
   
生产厂家英文名:
Chugai
该药品相关信息网址1:
http://www.chugai-pharm.co.jp/english/news/detail/20071023000000.html
原产地英文商品名:
Sigmart for injection 12mg 10 vials, cold chain product (storage at 2-8 degrees) extra charge for packaging
原产地英文药品名:
Nicorandil
中文参考商品译名:
Sigmart注射剂 12毫克 10瓶 冷链产品(储存在2-8度),需要额外的包装费用
中文参考药品译名:
喜革脈錠
原产地国家批准上市年份:
0000/00/00
英文适应病症1:
Angina
临床试验期:

中文适应病症参考翻译1:
狹心症
药品信息:
藥理作用 Sigmart為一種新型的鉀離子通道開啟劑,開啟鉀離子通道可 (1)模仿或加強心臟發生缺血時產生的preconditioning,具心肌保護作用。 (2)擴張細支冠狀動脈。 (3)降低後負荷。另Sigmart可釋出NO,故亦具有類硝酸鹽作用。合併二種作用機轉,對於抗心絞痛有藥理上之協同效果︰心肌保護作用。擴張粗支及細支冠狀動脈︰增加心臟之灌血流量。擴張靜脈及動脈︰降低前負荷及後負荷,減低心臟耗氧量。故Sigmart對於各種類型之狹心症均有效。 適應症 狹心症。 藥動力學 服用後0.5-1小時內可達最高血中濃度,與食物併服會延遲吸收,但不影響生體可用率。肝功能異常者會稍微延長其半衰期,但不需調整劑量。老年病患及腎功能異常者,均不影響其藥物動力,亦不需要調整劑量。 副作用 在14,323例中,有661例(46.1%)、817件副作用的發生(包括臨床檢查值的異常)。主要為頭痛515件(3.60%)、其他有噁心、嘔吐63件(0.44%)、眩暈21件(0.15%)、顏面潮紅20件(0.14%)、和倦怠感17件(0.12%)。 交互作用 與Sildenafil citrate(Viagra®) Vardenafil monohydro-chloride (Levitra®)併用會有增強降壓的效果。Nicorandil可促進cGMP的產生,而PDE-5抑制劑會抑制cGMP的分解;有觀於此,當與PDE-5抑制劑併用時,因為cGMP的產生增加而加強了本品的降壓效果。 禁忌 對已服用Sildenafil citrate及Vardenafil monohydrochloride的患者,請勿併用Sigmart。因為經由併用會有增強降壓的效果。 注意事項 1. 下面的患者必須謹慎的給藥:(1)嚴重的肝機能障礙患者;(2)青光眼患者。 2. 關於孕婦之給藥:對於孕婦用藥之安全性,因為尚未確立,所以對於正在懷孕中的婦女或是有可能懷孕的婦女,最好不要給藥。 Pharmacological effects Sigmart for a novel potassium channel opener, open potassium channels (1) to mimic or enhance the generation of cardiac ischemic preconditioning, a cardioprotective effect. (2) the expansion of fine coronary artery. (3) reduce afterload. Another Sigmart may release NO, hence making the classes nitrate effect. Merge two mechanism of action, for the anti-angina synergistic pharmacological effects on the ︰ myocardial protection. Expansion of coarse and fine ︰ increase coronary blood flow in the heart of irrigation. Expansion of veins and arteries ︰ reduce preload and afterload, reduce cardiac oxygen consumption. Therefore Sigmart valid for all types of angina. Indications Angina. Pharmacokinetic Up to within 0.5 to 1 hour after taking the maximum blood concentration, and serving of food and delay absorption, but does not affect the availability of the living body. Abnormal liver function is slightly longer half-life, but without dose adjustment. Elderly patients with renal dysfunction, the drug did not affect its power, nor need to adjust the dose. Side effect In 14,323 cases, there are 661 cases (46.1%), 817 occurrence of side effects (including abnormal clinical examination value). The main headache 515 (3.60%), other have nausea, vomiting 63 (0.44%), dizziness 21 (0.15%), facial flushing 20 (0.14%), and Burnout 17 (0.12%). Interaction With Sildenafil citrate (Viagra®) Vardenafil monohydro-chloride (Levitra®) and there will be enhanced with antihypertensive effect. Nicorandil can promote the generation of cGMP, and PDE-5 inhibitors inhibit the decomposition of cGMP; the concept of this, when combined with PDE-5 inhibitors and use, because increased production of cGMP and enhanced hypotensive effect of this product. Taboo The patient has been taking Sildenafil citrate and Vardenafil monohydrochloride, do with Sigmart. Because there will be enhanced through with antihypertensive effect. Precautions 1. The following must be carefully administered to the patient: (1) patients with severe liver dysfunction; (2) patients with glaucoma. 2. With regard to the administration of pregnant women: For the safety of the drug in pregnant women, because not yet been established, so for women who are pregnant or women who may become pregnant, it is best not to administration.
更新日期: 2014-09-23
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