您好,欢迎光临世界标品! 登录 注册(订药物标准品请用邮件联系我们)

SCITEK INTERNATIONAL (H.K.) LIMITED
Email: sciteck.hongkong@gmail.com
 

当前本网站药物产品种数共 8524 处方药 8148 非处方药 269 保健品/医疗用具 107

世界标品医药目录搜索(中英文):
世界各国官方药品目录搜索(英文):
世界标品医药知识搜索(中英文):

联系方式
国内客服电话:
国际免费电话:

咨询邮箱:
scimed.shanghai@shijiebiaopin.com
info@shijiebiaopin.com
pharmacy.shijiebiaopin1@gmail.com
pharmacy.shijiebiaopin2@gmail.com

  药店国别: 意大利药房
产地国家: 意大利
所属类别: 作用于消化系统药物->治疗腹部手术后出现的肠梗阻
处方药:处方药
包装规格: 500毫克/2毫升 3支
计价单位:
   
生产厂家英文名:
Bayer SpA
该药品相关信息网址1:
http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=0ed47f4b-5182-40b7-a440-9e7b06819d95
原产地英文商品名:
Bepanten Injection 500mg/2ml 3 Vials
原产地英文药品名:
Dexpantenolo
中文参考商品译名:
Bepanten 注射剂 500毫克/2毫升 3支
中文参考药品译名:
右泛醇
原产地国家批准上市年份:
0000/00/00
英文适应病症1:
paralytic ileus
临床试验期:
完成
中文适应病症参考翻译1:
肠梗阻
药品信息:
说明 泛醇是泛酸,一个B复合维生素的衍生物。泛醇注射液是一种无菌,无热原的水用作胃肠道刺激指示溶液。化学名称为D-(+ )-2,4 - 二羟基-N- (3 - 羟丙基)-3,3 - dimethybutylamide 。 每毫升含有D-泛醇250毫克的注射用水适量pH值(范围为4 - 7 )可与柠檬酸钠和/或柠檬酸进行调节。 临床药理学 泛酸是辅酶A ,其作为辅助因子用于多种涉及的乙酰基转移酶催化的反应中的前体。在乙酰胆碱的合成的最后一步是由乙酰基从acetylcoenzyme A中的乙酰胆碱转移到胆碱。乙酰胆碱是神经体液发射机在副交感神经系统中,因此维持肠道的正常功能。减少乙酰胆碱的含量会导致肠蠕动降低,在极端情况下,麻痹性肠梗阻。这种药物的作用的药理模式是未知的。在人体药代动力学数据不可用。 适应症 预防性使用腹部大手术后,立即以减少麻痹性肠梗阻的可能性。肠道收缩乏力引起腹胀,肛门排气术后或产后潴留,或术后延迟恢复肠道蠕动;麻痹性肠梗阻。 禁忌 没有已知的禁忌使用D-泛醇注射液。 警告 同时使用D-泛醇注射用药物如抗生素,麻醉药和巴比妥类药物期间也出现了原因不明的过敏性反应的罕见实例。 管理D-泛醇注射液直接进入静脉,不建议(见用法用量) 。 泛醇注射液不应琥珀胆碱后一小时内给药。 注意事项 一般 如果过敏反应的迹象显示, D-泛醇注射液时应停药。如果肠梗阻是机械性肠梗阻的辅助后果,主要应注意引导到阻塞。 麻痹性肠梗阻的管理包括任何液体和电解质紊乱纠正(尤其是低血钾症) ,贫血和低蛋白血症,治疗感染,避免在可能的这是众所周知的降低肠胃蠕动和胃肠道减压时立即大幅鼻饲药物胀得吸长肠管或使用。 药物相互作用 琥珀胆碱的影响似乎已经长期在一个女人服用泛醇。 生育的致癌性,致突变性和减值 - 目前还没有动物研究,以评估泛醇的生育能力的致癌,致突变,或减值。 怀孕 致畸作用 妊娠C类动物生殖研究尚未进行与D-泛醇注射液。它也不会知道当给予孕妇或可能影响生殖能力D-泛醇注射液是否会对胎儿造成伤害。泛醇注射液应给予孕妇 女人只有在明确需要。 哺乳母亲 目前还不知道这种药物是否会分泌至乳汁中。因为许多药物被排泄在人乳中,应谨慎时, D-泛醇注射液被给予哺乳妇女行使。 【儿童用药】 在儿童的安全性和有效性尚未确立。 不良反应 曾有过敏反应,并与泛醇的管理协会其他一些不良事件的报告单的报道很少。的因果关系是不确定的。一个病人有经验的瘙痒,刺痛,呼吸困难。另一名患者有皮肤的红色斑块。两名病人已经全身性皮炎和一个病人荨麻疹。 下面泛醇注射给药琥珀胆碱被中断了5分钟后一名患者经历短暂的呼吸困难。 1例患者出现血压明显,但略有下降泛醇,而在恢复室给药后。 1例患者肠绞痛一个半小时的药物给药后。 两名病人吐了下列管理和两名病人有腹泻后10天手术和D-泛醇注射液后。 一位老年患者的药物给药后情绪激动。 剂量与用法 预防手术后的麻痹性肠梗阻的: 250毫克(1毫升)或500毫克(2毫升)肌注。重复2小时,然后每6个小时,直到麻痹性肠梗阻的所有危险已经过去。 治疗麻痹性肠梗阻的: 500毫克( 2毫升)肌注。根据需要重复2小时,然后每6小时。 静脉给药: D-泛醇注射液2毫升( 500毫克)可以用第四散装混合溶液如葡萄糖或乳酸盐林格慢慢静脉内输注。 注射用的药品应肉眼检查有无颗粒物质和变色给药前,在溶液及容器许可。 DESCRIPTION Dexpanthenol is a derivative of pantothenic acid, a B complex vitamin. Dexpanthenol Injection is a sterile, nonpyrogenic, aqueous solution indicated for use as a gastrointestinal stimulant. The chemical name is D-(+)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethybutylamide. Each mL contains Dexpanthenol 250 mg in Water for Injection q.s. pH (range 4 - 7) may be adjusted with Sodium Citrate and/or Citric Acid. CLINICAL PHARMACOLOGY Pantothenic acid is a precursor of coenzyme A, which serves as a cofactor for a variety of enzyme-catalyzed reactions involving transfer of acetyl groups. The final step in the synthesis of acetylcholine consists of the choline acetylase transfer of acetyl group from acetylcoenzyme A to choline. Acetylcholine is the neurohumoral transmitter in the parasympathetic system and as such maintains the normal functions of the intestine. Decrease in acetylcholine content would result in decreased peristalsis and in extreme cases adynamic ileus. The pharmacological mode of action of the drug is unknown. Pharmacokinetics data in humans is unavailable. INDICATIONS AND USAGE Prophylactic use immediately after major abdominal surgery to minimize the possibility of paralytic ileus. Intestinal atony causing abdominal distention; postoperative or postpartum retention of flatus, or postoperative delay in resumption of intestinal motility; paralytic ileus. CONTRAINDICATIONS There are no known contraindications to the use of Dexpanthenol Injection. WARNINGS There have been rare instances of allergic reactions of unknown cause during the concomitant use of Dexpanthenol Injection with drugs such as antibiotics, narcotics and barbiturates. Administration of Dexpanthenol Injection directly into the vein is not advised (See Dosage and Administration). Dexpanthenol Injection should not be administered within one hour of succinylcholine. PRECAUTIONS General If any signs of a hypersensitivity reaction appear, Dexpanthenol Injection should be discontinued. If ileus is a secondary consequence of mechanical obstruction, primary attention should be directed to the obstruction. The management of adynamic ileus includes the correction of any fluid and electrolyte imbalance (especially hypokalemia), anemia and hypoproteinemia, treatment of infection, avoidance where possible of drugs which are known to decrease gastrointestinal motility and decompression of the gastrointestinal tract when considerably distended by nasogastric suction or use of a long intestinal tube. Drug Interactions The effects of succinylcholine appeared to have been prolonged in a woman administered dexpanthenol. Carcinogenicity, Mutagenicity, and Impairment of Fertility - There have been no studies in animals to evaluate the carcinogenic, mutagenic, or impairment of fertility potential of dexpanthenol. Pregnancy Teratogenic Effects Pregnancy Category C. Animal reproduction studies have not been conducted with Dexpanthenol Injection. It is also not known whether Dexpanthenol Injection can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Dexpanthenol Injection should be given to a pregnant woman only if clearly needed. Nursing Mothers It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Dexpanthenol Injection is administered to a nursing woman. Pediatric Use Safety and effectiveness in children have not been established. ADVERSE REACTIONS There have been a few reports of allergic reactions and single reports of several other adverse events in association with the administration of dexpanthenol. A causal relationship is uncertain. One patient experienced itching, tingling, difficulty in breathing. Another patient had red patches of skin. Two patients had generalized dermatitis and one patient urticaria. One patient experienced temporary respiratory difficulty following administration of dexpanthenol injection 5 minutes after succinylcholine was discontinued. One patient experienced a noticeable but slight drop in blood pressure after administration of dexpanthenol while in the recovery room. One patient experienced intestinal colic one-half hour after the drug was administered. Two patients vomited following administration and two patients had diarrhea 10 days post-surgery and after Dexpanthenol Injection. One elderly patient became agitated after administration of the drug. DOSAGE AND ADMINISTRATION Prevention of post-operative adynamic ileus: 250 mg (1 mL) or 500 mg (2 mL) intramuscularly. Repeat in 2 hours and then every 6 hours until all danger of adynamic ileus has passed. Treatment of adynamic ileus: 500 mg (2 mL) intramuscularly. Repeat in 2 hours and then every 6 hours as needed. Intravenous administration: Dexpanthenol Injection 2 mL (500 mg) may be mixed with bulk I.V. solutions such as glucose or Lactated Ringer’s and slowly infused intravenously. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
调控比例: 100%
订购表单下载
Copyrights © 2010,2011,2012 www.ShiJieBiaoPin.com, Inc., All rights Reserved www.ShiJieBiaoPin.com, Inc.
客服工作时间:太平洋时间18:00-24:00
国内客服电话:     国际免费电话:
友情提示:以上电话为免费电话,无需您承担任何费用,世界标品提供中文客服,请您放心拨打!
电子邮箱:sciteck.hongkong@gmail.com, 15901965168@163.com