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  药店国别: 美国药房
产地国家: 美国
所属类别: 心血管系统药物->抗高血压药物
处方药:处方药
包装规格: 40毫克/片 100片/盒
计价单位:
  点击放大  
生产厂家中文参考译名:
第一三共
生产厂家英文名:
DAIICHI SANKYO
该药品相关信息网址1:
http://www.benicar.com/
该药品相关信息网址2:
http://www.drugs.com/benicar.html
该药品相关信息网址3:
http://www.rxlist.com/benicar-drug.htm
原产地英文商品名:
BENICAR DS PK 40mg/Tablet 100Tablets/box
原产地英文药品名:
OLMESARTAN MEDOXOMIL
中文参考商品译名:
傲坦板装 40毫克/片 100片/盒
中文参考药品译名:
奥美沙坦酯
原产地国家批准上市年份:
2002/04/25
英文适应病症1:
Hypertension
临床试验期:
完成
中文适应病症参考翻译1:
高血压
药品信息:

友情提示:UD 只按箱卖给医院共2400粒。

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 详细处方信息以本药内容附件PDF文件(200952600304813.pdf)的“原文Priscribing Information”为准
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部分中文BENICAR处方资料(仅供参考)

【商品名】傲坦
【英文名称】BENICAR
【通用名】奥美沙坦酯片
【适应症】高血压治疗
【药品特性】
1.强效:降压幅度更大,达标率更高
2.快速:二周达最大疗效
3.独特:双链结构和反向激动机制, 保证更出色的降压, 达标率更高
4.放心:药物相互作用少, 使用患者群广,不经P450代谢,肝、肾双通道排泄
    傲坦 (奥美沙坦酯)作为最新的 ARB, 于 2002 年 5 月在美国率先上市。目前 , 其美国市场的处方量已升至ARB 类药物的第 3 位 , 仅次于缬沙坦和氯沙坦。

    作为 ARB 的后起之秀,傲坦具有以下特点:
傲坦-独特的药代动力学
    奥美沙坦酯口服后经胃肠道吸收,迅速、完全地去酯化水解为奥美沙坦,绝对生物利用度大约是 26% 。口服给药 1 ~ 2 小时之后即达血药峰值浓度。进食不影响奥美沙坦的生物利用度。
    奥美沙坦酯半衰期约为 13 小时,大约有 35% ~ 50% 吸收的药物从尿液中排出,其余经胆汁从粪便中排出。
    奥美沙坦酯不通过肝脏细胞色素 P 450 系统代谢,对 P 450 酶没有影响。因此,不会出现与这些酶抑制、诱导或者代谢相关的药物相互作用。
    以上特点保证了奥美沙坦酯具有 1 天 1 次全天降压 , 肝肾功能障碍者服用方便 , 以及与其他药物同时应用时相互作用可能较少等优点。
傲坦-卓越的降压疗效
    每日一次口服奥美沙坦酯片,降压效果可维持 24 小时,收缩压和舒张压下降的谷 - 峰比值在 60 ~ 80% 。降压作用在一周内起效,在二周后达到明显的效果。并可在长达 1 年的治疗中维持相同的降压效果,且不会出现耐药。停药后不出现血压反跳。年龄和性别并不影响奥美沙坦酯的降压作用。
    7 个安慰剂对照的临床试验(总共研究了 2693 例原发性高血压患者)证实:每日一次奥美沙坦酯可显著性降低舒张压和收缩压,奥美沙坦酯的降压作用与剂量呈相关性。每日 20mg 奥美沙坦酯-可使坐位血压下降约 10/6mmHg ;每日 40mg 奥美沙坦酯-可使坐位血压下降约 12/7mmHg 。
    一项随机、双盲、平行的多中心研究,比较了多种 ARB 类药物以起始剂量治疗 8 周后的降压作用。该研究入选 578 例应用安慰剂后坐位舒张压在 100 mmHg~115 mmHg 的患者 , 分别服用奥美沙坦酯 20 mg/ 日,氯沙坦钾 50 mg/ 日,缬沙坦 80 mg/ 日和厄贝沙坦 150 mg/ 日。在第 2 周时以奥美沙坦酯组下降幅度最大 , 收缩压和舒张压下降幅度与其他各组均有显著差异 (P<0.05) 。 8 周时,奥美沙坦酯组舒张压下降幅度仍然明显大于其他组 , 具有显著差异 (P<0.05) 。
    另一项随机、双盲的研究比较了奥美沙坦酯 20 mg/ 日 (320 例 ) 与坎地沙坦 8 mg/ 日 (325 例 ) 对轻、中度高血压的疗效。结果显示:在用药后 1 、 2 和 8 周时,奥美沙坦酯的降压效果更显著 (P<0.05) 。
    傲坦 ( 奥美沙坦酯 ) 在中国的注册临床研究显示:在 4 周时,奥美沙坦酯比氯沙坦钾更显著的降低血压;在 8 周时,奥美沙坦酯降低舒张压 12.94 mmHg ,也较氯沙坦钾显著。这与国际大型临床研究的结果一致。

Benicar
Generic Name: olmesartan (OL me SAR tan)
Brand Names: Benicar

What is Benicar?
Benicar (olmesartan) is in a group of drugs called angiotensin II receptor antagonists. Benicar keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.

Benicar is used to treat high blood pressure (hypertension) in adults and children who are at least 6 years old. It is sometimes given together with other blood pressure medications.

Benicar may also be used for other purposes not listed in this medication guide.

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Important information about Benicar
Stop using Benicar and tell your doctor right away if you become pregnant. Benicar can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

You should not use Benicar if you are allergic to olmesartan. Drinking alcohol can further lower your blood pressure and may increase certain side effects of Benicar. Do not use potassium supplements or salt substitutes while you are taking Benicar, unless your doctor has told you to.

Your blood pressure will need to be checked often. Visit your doctor regularly.

Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

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Before taking Benicar
You should not take Benicar you are allergic to olmesartan.

If you have any of these other conditions, you may need a dose adjustment or special tests:
kidney disease;
liver disease;
congestive heart failure; or
if you are dehydrated.

FDA pregnancy category D. Do not use Benicar if you are pregnant. Stop using Benicar and tell your doctor right away if you become pregnant. Benicar can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control while taking Benicar. It is not known whether olmesartan passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are taking olmesartan.

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How should I take Benicar?
Take Benicar exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results.

You may take Benicar with or without food.

Your blood pressure will need to be checked often. Visit your doctor regularly.

Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Store Benicar at room temperature away from moisture and heat.

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What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

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What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include extreme dizziness, fast or slow heartbeat, or fainting.

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What should I avoid while taking Benicar?
Drinking alcohol can further lower your blood pressure and may increase certain side effects of Benicar. Do not use potassium supplements or salt substitutes while you are taking Benicar, unless your doctor has told you to.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

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Benicar side effects
Get emergency medical help if you have any of these signs of an allergic reaction to Benicar: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:
feeling like you might pass out;
urinating less than usual or not at all;
chest pain, fast heart rate; or
swelling in your hands or feet.

Less serious Benicar side effects may include:
dizziness;
joint or muscle pain;
back pain;
stomach pain, nausea, diarrhea;
mild itching or skin rash; or
weakness.

This is not a complete list of Benicar side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

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What other drugs will affect Benicar?
Tell your doctor about all other medicines you use, especially blood pressure medications such as a diuretic (water pill).

There may be other drugs that can interact with Benicar. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

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Where can I get more information?
Your pharmacist can provide more information about Benicar.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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 详细处方信息以本药内容附件PDF文件(200952600304813.pdf)的“原文Priscribing Information”为准
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更新日期: 2012-4-1
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