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  药店国别: 英国药房
产地国家: 英国
所属类别: 影响血液及造血系统药物->抗血小板凝聚药
处方药:处方药
包装规格: 1.5毫克/瓶
计价单位:
  点击放大  
生产厂家中文参考译名:
葛兰素史克
生产厂家英文名:
GLAXOSMITHKLINE LLC
该药品相关信息网址1:
http://www.rxlist.com/flolan-drug.htm
该药品相关信息网址2:
http://www.drugs.com/cdi/flolan.html
该药品相关信息网址3:
http://www.gsk.com/products/prescription-medicines/flolan.htm
原产地英文商品名:
FLOLAN 1.5 MG POWDER AND SOLVENT FOR SOLUTION FOR INFUSION
原产地英文药品名:
EPOPROSTENOL SODIUM
中文参考商品译名:
服疗能 粉剂和溶剂解输液 1.5毫克/毫升/瓶
中文参考药品译名:
依前列醇钠
原产地国家批准上市年份:
1995/09/20
英文适应病症1:
Anti-platelet aggregation
英文适应病症2:
Cardiopulmonary bypass surgery
英文适应病症3:
Protection of platelet
英文适应病症4:
Instead of heparin
英文适应病症5:
Cardiovascular disease
临床试验期:
完成
中文适应病症参考翻译1:
抗血小板凝集
中文适应病症参考翻译2:
心肺分流手术
中文适应病症参考翻译3:
保护血小板
中文适应病症参考翻译4:
代替肝素
中文适应病症参考翻译5:
心血管疾病
药品信息:

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 详细处方信息以本药内容附件PDF文件(2011112018215638.pdf)的“原文Priscribing Information”为准
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部分中文依前列醇处方资料(仅供参考)

依前列醇Epoprostenol 
中文别名:
依前列醇、环前列烯醇钠、环依前列烯醇、前列环素、前列腺素I2

英文别名:Cycloprostin、Flolan、Prostacyclin、Prostacyclin Sodium
 
药品类别:其它神经系统用药 
 
药理药动
  本品广泛存在于哺乳动物体内,它在血管壁中形成,也从肺作为循环激素释出。
在正常生理条件下,它能阻止血小板粘连于正常血管壁,保证血流通畅,但在损伤时,主要在血小板中形成的凝血恶烷即逆转其作用。
本品可防止血小板凝固,甚至能使血小板凝块解聚。
本品能够直接防止血小板接触非血管表面时发生的活化与聚集。因此,它可在体外循环时防止血栓形成。同时,它还有血管扩张活性,可产生降压作用。动物实验证明,本品可防止血小板凝固,防止微小血栓形成,甚至还能使血小板凝块解聚,它引起平滑肌舒张,血管扩张。

适应症
  本品为抗血小板凝集药物,可用于心肺分流手术,活性炭血液灌注时保护血小板功能,肾透析时代替肝素,也用于心血管疾病的研究(包括心绞痛及外周血管疾患)。

用法用量
  临用时以pH 10.5的含甘氨酸的专用缓冲剂溶解。心肺分流术:先连续静滴10ng/(kg·min),在分流术中用20ng/(kg·min)静滴。
活性炭血液灌注:静滴2~16ng/(kg·min)。
肾透析:静滴5ng/(kg·min)。

制剂与规格:粉针剂:每支含本品500μg。
 
贮藏:在5℃保存,有效期为1年以上。

不良反应
  本品不良反应有低血压、心率增快、颜面潮红、头痛、恶心和呕吐,另有报道有胃痛、感觉不安、腿痛、高血糖症等。一般并不严重。


Flolan
Pronunciation: E-poe-PROST-e-nol
Generic Name: Epoprostenol
Brand Name: Examples include Flolan and Veletri

Flolan is used for:
Treating high blood pressure in the blood vessels of the lungs (pulmonary arterial hypertension [PAH]) to improve exercise capacity.

Flolan is a prostaglandin. It works by relaxing the blood vessels, which increases blood flow to the lungs.

Do NOT use Flolan if:
•you are allergic to any ingredient in Flolan or to a similar medicine (eg, treprostinil)
•you have congestive heart failure caused by severe left-sided heart problems
•you have previously taken Flolan and developed fluid in the lungs (pulmonary edema)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Flolan:
Some medical conditions may interact with Flolan. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
•if you are pregnant, planning to become pregnant, or are breast-feeding
•if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
•if you have allergies to medicines, foods, or other substances

Some MEDICINES MAY INTERACT with Flolan. Tell your health care provider if you are taking any other medicines, especially any of the following:
•Diuretics (eg, furosemide, hydrochlorothiazide), medicines for high blood pressure, or other vasodilators (eg, minoxidil) because the risk of low blood pressure may be increased
•Anticoagulants (eg, warfarin) or antiplatelet medicines (eg, aspirin, clopidogrel) because the risk of bleeding may be increased by Flolan
•Digoxin because the risk of its side effects may be increased by Flolan

This may not be a complete list of all interactions that may occur. Ask your health care provider if Flolan may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Flolan:
Use Flolan as directed by your doctor. Check the label on the medicine for exact dosing instructions.
•Flolan is given as an intravenous (IV) infusion. If you will be using Flolan at home, a health care provider will teach you how to use it. Be sure you understand how to use Flolan. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
•Flolan must be mixed with a certain type of solution. Do not use any other type of solution to mix Flolan. After Flolan has been mixed, do not combine or mix it with any other solutions or medicines. Contact your doctor or pharmacist if you are unsure which type of solution to mix Flolan with.
•Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
•If you miss a dose of Flolan, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Flolan.

Important safety information:
•Flolan may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Flolan with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
•Do not suddenly stop using Flolan. You may experience a recurrence of PAH symptoms (eg, shortness of breath, dizziness, weakness). Discuss any questions or concerns with your doctor.
•Flolan may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
•Flolan should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
•PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Flolan while you are pregnant. It is not known if Flolan is found in breast milk. If you are or will be breast-feeding while you use Flolan, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Flolan:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Abnormal skin sensations (eg, burning, numbness, tingling); agitation; anxiety; back pain; bleeding, pain, redness, or swelling at the injection site; constipation; diarrhea; dizziness; flu-like symptoms (eg, mild fever, mild chills, muscle aches); flushing; headache; loss of appetite; muscle, bone, joint, or jaw pain; nausea; nervousness; stomach pain or upset; sweating; tiredness; trouble sleeping; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or dark urine; chest pain; dark, tarry, or bloody stools; fainting; fast, slow, or irregular heartbeat; light-headedness; new or worsening shortness of breath; pale skin; severe or persistent dizziness; skin ulcers; symptoms of infection (eg, fever, chills, sore throat, cough); tremor; unusual or increased bruising or bleeding; unusual tiredness or weakness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include diarrhea; fainting; flushing; headache; light-headedness; nausea; rapid heart rate; severe or persistent dizziness; vomiting.

Proper storage of Flolan:
Flolan is usually handled and stored by a health care provider. If you are using Flolan at home, store Flolan as directed by your pharmacist or health care provider. Keep Flolan out of the reach of children and away from pets.

General information:
•If you have any questions about Flolan, please talk with your doctor, pharmacist, or other health care provider.
•Flolan is to be used only by the patient for whom it is prescribed. Do not share it with other people.
•If your symptoms do not improve or if they become worse, check with your doctor.
•Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Flolan. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

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 详细处方信息以本药内容附件PDF文件(2011112018215638.pdf)的“原文Priscribing Information”为准
---------------------------------------------------------------

更新日期: 2013-09-23
附件:




2011112018215638.PDF    

 
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