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 详细处方信息以本药内容附件PDF文件（201261123511310.PDF）的“原文Priscribing Information”为准
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 部分中文萘普生钠处方资料（仅供参考）

中文药名: 萘普生钠片

药效类别: 消炎镇痛药

通用药名: NAPROXEN SODIUM

别　　名: Aleve, Anaprox, Antalgin, Apranax, Apronax, Danaprox, Femex, Flanax, Naprogesic, Naprosian, Naprosyn, Naxen, Nycopren, Synflex

化学名称: 2-Naphthalenacetic acid, 6-methoxy-α-methyl-, sodium salt

性状: 萘普生是一种2-芳基丙酸类（布洛芬）的非甾体抗炎药。白色或类白色结晶性粉末，几乎无臭。可在脂类物质中溶解，在水中几乎不溶。它的熔点是153 °C。

适应症
对类风湿性关节炎、骨关节炎、强直性脊椎炎、痛风、运动系统（如关节、肌肉及腱）的慢性变性疾病及轻、中度疼痛如痛经等，均有肯定疗效。

用法用量
口服：开始每日剂量５００～７５０ｍｇ，维持量每日３７５～７５０ｍｇ，分早晨及傍晚２次服用。轻、中度疼痛或痛经时，开始用５００ｍｇ，必需时经６～８小时后再服２５０ｍｇ，日剂量不得超过１２５０ｍｇ。
任何疑问，请遵医嘱！

副作用与警告
正如其他非甾体抗炎药一样，萘普生可以抑制钠和锂的代谢。服用该药的同时服用锂补剂时必须十分注意。萘普生等非甾体抗炎药也不应与水杨酸类药物(如阿司匹林) (因为药物会降低彼此疗效)或者与抗凝血剂 (会增加出血的风险)一起服用。萘普生钠药物不能让钠敏高血压患者服用，因为这会给患者带来潜在的发病危险。
2006年8月，Birth Defects Research杂志B刊[2]刊登了三个月孕龄内的孕妇服用了包括萘普生在内的非甾体抗炎药的研究结果，结果表明该类药物会增加胎儿先天缺陷的可能性，特别是先天心血管病。

注意事项
1.长期服用耐受良好，不良反应主要为胃肠道轻度和暂时不适。偶有恶心、呕吐、消化不良、便秘、胃肠道出血、失眠或嗜睡、头痛、头晕、耳鸣、瘙痒、皮疹、血管神经性水肿、视觉障碍及出血时间延长，一般不需中断治疗。
2.与乙酰水杨酸等非甾体抗炎药有交叉过敏反应，禁用于对本品及对乙酰水杨酸过敏的病人。
3.对伴有消化性溃疡或有消化性溃疡病史者慎用；对有活动性胃及十二指肠溃疡病人应在严格监督下使用。
4.本品可加强双香豆素的抗凝血作用。
5.与丙磺舒合用时，可增加本品的血药水平及明显延长本品的血药半衰期。

规格
片剂：每片２75ｍｇ。

GENERIC NAME: naproxen

BRAND NAME: Anaprox, Naprelan, Naprosyn, Aleve

DRUG CLASS AND MECHANISM: Naproxen belongs to a class of drugs called nonsteroidal antiinflammatory drugs (NSAIDs). Other members of this class include ibuprofen (Motrin), indomethacin (Indocin), nabumetone (Relafen) and several others. These drugs are used for the management of mild to moderate pain, fever, and inflammation. They work by reducing the levels of prostaglandins, chemicals that are responsible for pain, fever, and inflammation. Naproxen blocks the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower concentrations of prostaglandins. As a consequence, inflammation, pain and fever are reduced. Naproxen was approved by the FDA in December 1991.

PRESCRIPTION: Yes; (Aleve, no)

GENERIC AVAILABLE: Yes

PREPARATIONS:
Anaprox (tablets): 275 and 550 mg;
Naprosyn (tablets): 250, 375, and 500 mg;
Naprosyn suspension: 125 mg/5ml;
EC-Naprosyn: 375 mg,
Aleve: 220 mg;
Naprelan (controlled-release tablets): 375 and 500mg.

STORAGE: Naproxen should be stored at room temperature: 15-30 C (59-86 F).

PRESCRIBED FOR: Naproxen is used for the treatment of mild to moderate pain, inflammation, and fever.

DOSING: The usual adult dose is 250-500 mg twice daily using regular naproxen tablets. The usual dose for Naprelan controlled release tablets is 750 to 1000 mg given once daily. For EC-Naprosyn, the usual dose is 375-500 mg twice daily. Naproxen should be given with food to reduce upset stomach.

DRUG INTERACTIONS: Naproxen is associated with several suspected or probable interactions that affect the action of other drugs. The following examples are the most common suspected interactions.

Naproxen may increase the blood levels of lithium (Eskalith) by reducing the excretion of lithium by the kidneys. Increased levels of lithium may lead to lithium toxicity.

Naproxen may reduce the blood pressure lowering effects of blood pressure medications. This may occur because prostaglandins play a role in the regulation of blood pressure.

When naproxen is used in combination with methotrexate or aminoglycosides (for example, gentamicin) the blood levels of the methotrexate or aminoglycoside may increase, presumably because the eliminationfrom the body is reduced. This may lead to more methotrexate or aminoglycoside-related side effects.

Individuals taking oral blood thinners or anticoagulants [for example, warfarin, (Coumadin)] should avoid naproxen because naproxen also thins the blood, and excessive blood thinning may lead to bleeding.

PREGNANCY: There are no adequate studies of naproxen in pregnant women. Therefore, naproxen is not recommended during pregnancy.

NURSING MOTHERS: A small amount of naproxen is excreted in breast milk. Because the concentration in breast milk is low, breastfeeding while taking naproxen probably is not harmful to the infant.

SIDE EFFECTS: The most common side effects from naproxen are rash, ringing in the ears, headaches, dizziness, drowsiness, abdominal pain, nausea, diarrhea, constipation, heartburn, fluid retention and shortness of breath.

NSAIDs reduce the ability of blood to clot and therefore increase bleeding after an injury. Naproxen also may cause stomach and intestinal bleeding and ulcers. Sometimes, stomach ulceration and intestinal bleeding can occur without any abdominal pain. Black tarry stools, weakness, and dizziness upon standing may be the only signs of the bleeding.

People who are allergic to other NSAIDs should not use naproxen. NSAIDs reduce the flow of blood to the kidneys and impair function of the kidneys. The impairment is most likely to occur in patients with preexisting impairment of kidney function or congestive heart failure, and use of NSAIDs in these patients should be done cautiously. Individuals with asthma are more likely to experience allergic reactions to naproxen and other NSAIDs. Fluid retention, blood clots, heart attacks, hypertension, and heart failure have also been associated with the use of NSAIDs.

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 详细处方信息以本药内容附件PDF文件（201261123511310.PDF）的“原文Priscribing Information”为准
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