药品信息:
--------------------------------------------------------------- 部分中文利百素处方资料(仅供参考) ---------------------------------------------------------------
【 商品名 】 利百素Reparil
【中文名称】 复方七叶皂苷凝胶
【产品英文名称】 Compound Aescin Gel
【功效主治】 挫伤、扭伤、拉伤、血肿、腱鞘炎、脊椎疼痛征候群(颈椎征候群、腰痛、坐骨神经痛)。
【化学成分】 本品为复方制剂,其组分为:七叶皂苷、水杨酸二乙胺。聚丙烯酸、聚乙二醇-6辛(癸)酸甘油酯,依地酸钠、氨基丁三醇,2-丙醇、芳香剂。
【药理作用】 七叶皂苷的作用部位为血管壁。炎症反应时,渗透性增加,七叶皂苷减少外渗的体液使其流入组织周围,起到抑制渗出的作用,并且它还能促进水肿的再吸收,作用机制是改变所涉及的毛细血管的渗透性,七叶皂苷还能增强毛细血管的阻力,抑制炎症过程和改善微循环。 水杨酸乙二胺(DEAS)有明显的止痛效果,它容易透过皮肤,在疾患部位的深处发挥止痛作用。另外,DEAS的抗炎作用,可加强七叶皂苷的抗炎效果,由此起到对抗病因的作用。用安慰剂作对照,采用双盲法,用引起血肿(注射血肿物)的实验模型,对随机三个组的个人进行药理学研究,该研究证实利百素凝胶有缓解触痛和促进血肿吸收作用。 在初始治疗的24小时以及随后的整个19天,与安慰剂和单独用七叶皂苷或DEAS比较,利百素凝胶能明显降低触痛的程度,而两种物质(七叶皂苷和DEAS)的单独作用又明显好于安慰剂,用相同的模型与参与制剂双氯芬酸和安慰剂比较,两种活性成分都有明显的优势;利百素凝胶与双氯芬酸比较,利百素凝胶占优势。
【药物相互作用】 尚不明确。
【不良反应】 皮肤过敏反应可偶见。用药期间,一旦发生不良反应,请及时通告您的医生或药师。
【禁忌症】 利百素凝胶不能用于皮肤破裂作处,粘膜表面或放射治疗的放射野。
【产品规格】 20g/支
【用法用量】 除非有特别需要,通常涂一薄层凝胶于患处,每日一次或多次。虽可加以轻轻按摩,但不按摩亦能渗入皮肤。治疗期限:本品可以较长期应用,至症状消失为止。
【贮藏方法】 在30℃以下干燥处保存。有效期:5年,超过药品有效期,请勿再使用。
【注意事项】 请将药品置于儿童取不到的地方。
REPARIL®-Gel SCHEDULING STATUS: S1
PROPRIETARY NAME (and dosage form):
REPARIL®-Gel COMPOSITION: 100 g contains Aescin 1,0 g Diethylamine salicylate 5,0 g
PHARMACOLOGICAL CLASSIFICATION: A.13.9 (Dermatological preparations - special combinations)
PHARMACOLOGICAL ACTION: Reparil-Gel has analgesic properties.
INDICATIONS: Symptomatic relief of pain associated with superficial soft tissue injuries, such as certain sports injuries. Provides temporary relief from the minor pain and stiffness or rheumatism and muscle soreness.
CONTRA-INDICATIONS: Hypersensitivity to the ingredients. Do not apply to broken skin and excessively raw areas.
DOSAGE AND DIRECTIONS FOR USE: Unless otherwise directed, a thin layer of the gel should be applied to the skin over the affected area several times daily.
SIDE-EFFECTS AND SPECIAL PRECAUTIONS: Erythema. Desquamation. Urticaria and angio-neurotic oedema may occur in aspirin sensitive patients following exposure to local application. Due to its alcohol content, Reparil-Gel should not be applied to areas of eczema or ulceration, nor to skin exposed to therapeutic irradiation, but only to the surrounding parts in order to avoid a possible burning sensation.
KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT: Systemic poisoning may occur from application to very large areas of skin.
IDENTIFICATION: A transparent, pale yellow, non-greasy, non-staining, alcohol based gel with a characteristic odour.
PRESENTATION: Tubes of 20 g, 40 g and 100 g.
STORAGE INSTRUCTIONS: Keep the tube tightly closed. Store at room temperature (below 25°C). Keep out of reach of children.
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