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  药店国别: 美国药房
产地国家: 美国
所属类别: 神经系统药物->抗抑郁药
处方药:处方药
包装规格: 5毫克/5毫升 240毫升/瓶
计价单位:
  点击放大  
生产厂家英文名:
Amneal Pharmaceuticals of New York, LLC
该药品相关信息网址1:
http://www.lexapro.com/
该药品相关信息网址2:
http://www.drugs.com/lexapro.html
该药品相关信息网址3:
http://www.rxlist.com/lexapro-drug.htm
原产地英文商品名:
ESCITALOPRAM OXALATE SOLUTION(LEXAPRO GENERIC) 5mg/5ml 240mls/bottle
原产地英文药品名:
ESCITALOPRAM OXALATE
中文参考商品译名:
艾司西酞普兰溶液剂(来士普仿制药) 5毫克/5毫升 240毫升/瓶
中文参考药品译名:
艾司西酞普兰
原产地国家批准上市年份:
0000/00/00
英文适应病症1:
MDD
英文适应病症2:
GAD
临床试验期:
完成
中文适应病症参考翻译1:
重症抑郁症
中文适应病症参考翻译2:
广泛性焦虑
药品信息:

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 详细处方信息以本药内容附件PDF文件(200972621322124.pdf)的“原文Priscribing Information”为准
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部分中文来士普处方资料(仅供参考)

【商品名】来士普

【通用名】艾司西酞普兰

【英文商品名】Lexapro

【英文通用名】Escitalopram

【作用机制】艾司西酞普兰增进中枢神经系统5-羟色胺(5-HT)能的作用,抑制5-羟色胺的再摄取,临床用于抑郁症的治疗。动物研究表明,艾司西酞普兰为选择性5-羟色胺再摄取抑制剂(SSRI),而对去甲肾上腺素和多巴胺再摄取作用微弱,其作用为西酞普兰右旋对映体作用的100倍。艾司西酞普兰对5-羟色胺1-7受体或其他受体包括α和β肾上腺素、多巴胺1-5、组胺1、蕈毒碱1-5和苯二氮卓受体无作用或非常小,另外对Na+、K+、Cl-和Ca++离子通道无作用。

【适应证】
1. 重症抑郁症(MDD)的治疗:重症抑郁症主要表现显著或持久的情绪低落或燥动情绪(至少持续2周),主要包括以下症状:情绪低落、兴趣减少、体重或食欲明显变化、失眠或嗜睡、精神运动兴奋或迟缓、过度疲劳、内疚或自卑感、思维迟缓或注意力不集中、自杀企图或念头。
2 、广泛性焦虑(GAD):表现为过度的焦虑和烦恼,至少持续6个月。主要有以下症状:烦燥不安、易疲劳、注意力不集中、兴奋、肌肉紧张和睡眠障碍。

【用法与用量】
1.重症抑郁症:起始剂量一日一次10mg,一周后可以增至一日一次20mg,早晨或晚上口服。一般情况下应持续几个月甚至更长时间的治疗。老年患者或肝功能不全者建议一日一次10mg·,轻度或中度肾功能不全者无需调节剂量。严重肾功能不全者慎用。
2.广泛性焦虑:起始剂量一日一次10mg,一周后可以增至一日一次20mg,早晨或晚上口服。至少停用单胺氧化酶抑制剂(MAOI)14天后才可以调换本药,同样,停用本药14天后才可以用单胺氧化酶抑制剂。停药时应逐渐减量。

【药物不良反应】约5%的患者有失眠、阳萎、恶心、便秘、多汗、口干、疲劳、嗜睡。约2%的患者有头痛、上呼吸道感染、背痛、咽炎和焦虑等。偶见报道可引起躁狂或轻度躁狂或低钠血。有惊厥史的患者应慎用。实验室参数没有明显的改变。心电图无明显异常。

【药物相互作用】禁与单胺氧化酶抑制剂并用, 与酒精和中枢神经系统药物(例如抗抑郁药)并用时应慎重。与阿司匹林、华法令等抗凝血药合用时可能引起上消化道出血的危险应慎用。锂盐可能增加艾司西肽普兰的作用,合用时应慎用。酶诱导剂卡马西平可能增加艾司西肽普兰的代谢,两者合用时应增加后者的剂量。与美托洛尔合用对患者的血压和心率没有明显影响。艾司西肽普兰不应与西肽普兰合用。

【注意事项】肝、肾功能不全者,有惊厥史或心脏病患者、甲状腺疾病、电解质紊乱、有其他精神疾病(例如双相情感障碍)或自杀念头者应慎用。 服药期间不宜操作机器, 孕妇或哺乳期妇女应慎用,对婴幼儿的安全性没有临床资料。对本品或西肽普兰过敏的患者应禁用

Lexapro.
Lexapro (escitalopram) is an antidepressant that works by restoring the balance of chemicals in the bran. This is a SSRI (selective serotonin reuptake inhibitor) used to treat depression and anxiety in people to whom it was prescribed. Never combine this medicine with any of the following MAO inhibitors as a dangerous reaction is possible: phenelzine, rasagiline, selegiline, isocarboxazid, and tranylcypromine. At least 14 days are supposed to pass before you will be table to take Lexapro after taking your last dose of any of the MAO inhibitors mentioned. Make sure you always tell your health care provider about any other medicines you are taking at the moment, such as blood thinners, almotriptan, zolmitriptan, cimetidine, frovatriptan, lithium, and any other antidepressants. Some drugs you are taking may add to the sleepiness Lexapro can cause, so you will need to be very careful when combining it with seizure or anxiety medications, narcotic pain medicines, cold or allergy medicines, sleeping pills, and muscle relaxers. Some people taking this medication may get suicidal at the beginning of the treatment. The risk is higher for those younger than 24, so if you belong to this age group your doctor will have you show up for regular check ups during the first couple of months of your treatment. Make sure you keep taking this medicine even if you feel no improvement, as it may take you up to 4 weeks to feel the effects of taking Lexapro. This medicine is not intended for patients younger than 12 and you are not supposed to give to your child if he or she is younger than that. The following side effects are sometimes reported by patients taking Lexapro: dry mouth, dizziness, ringing in your ears, insomnia, drowsiness, weight changes, gas, mild nausea, decreased sex drive, constipation, heartburn, and upset stomach. The side effects mentioned are minor (insignificant). You will probably not need to report them to your health care provider, as they are unlikely to last for too long. The mild side effects mentioned most often indicate your body is adjusting to the dose prescribed – only doing so a bit slower than usual. However, there are some serious side effects sometimes possible. Your doctor will need to be notified of the fact you develop any of the following serious side effects: trouble concentrating, diarrhea, fast or uneven heartbeats, shallow breathing, loss of coordination, tremors, high fever, vomiting, memory problems, loss of appetite, and rigid muscles. Avoid taking more of this medicine, even if you missed a dose. The missed dose needs to be taken as soon as possible except for the cases hen you are going to take the next dose pretty soon. In that case you will need to skip the dose you missed and go back to the regular dosing schedule. Taking a double dose can cause an overdose and it unlikely to make your treatment more successful. The following symptoms of an overdose are possible: dizziness, confusion, seizures, tremor, vomiting, sweating, rapid heartbeat, and nausea.

What is Lexapro?
•Lexapro (escitalopram oxalate) is a selective serotonin reuptake inhibitor (SSRI)
•Lexapro is available by prescription only

Lexapro has been proven safe and effective for the acute and maintenance treatment of MDD in adults and adolescents (ages 12-17) and for the acute treatment of anxiety (GAD) in adults.
•Lexapro has been prescribed to over 18 million U.S. adults
•Lexapro 10mg/day may significantly improve the symptoms of depression (MDD) in adults and adolescents (aged 12-17) and anxiety (GAD) for adults

How Lexapro works
Lexapro is believed to work by increasing serotonin, a substance in the brain believed to influence mood.

How SSRIs work
Although the brain chemistry involved in depression or anxiety is not fully understood, it is widely recognized that chemical messengers facilitate communication between nerve cells in the brain and are involved in regulating many aspects of behavior and mood. These chemicals are called neurotransmitters and it is believed that neurotransmitter imbalances play an important role in the development of depression and anxiety. Serotonin is a neurotransmitter that has been clearly linked with most, if not all, forms of depression. SSRIs are believed to work by blocking the reabsorption (reuptake) of serotonin in the brain, thus increasing available serotonin.

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 详细处方信息以本药内容附件PDF文件(200972621322124.pdf)的“原文Priscribing Information”为准
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更新日期: 2014-08-12
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