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 详细处方信息以本药内容附件PDF文件（20127318261339.PDF）的“原文Priscribing Information”为准
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 部分中文氟比洛芬处方资料（仅供参考）

氟比洛芬钠滴眼液|Ocufen(flurbiprofen drops)
英文药名: Ocufen(flurbiprofen drops)

中文药名: 欧可芬,氟比洛芬钠滴眼液

生产厂家: Allergan

药品名称
通用名：氟比洛芬钠滴眼液
英文名：Flurbiprofen Sodium Eye Drops

主要成份
本品主要成份为：氟比洛芬钠。其化学名称为：消旋-2-(2-氟-4-联苯基)-丙酸钠。

性状
无色澄明液体。

药理作用
氟比洛芬为非甾体消炎药，动物研究证明具有镇痛、解热和消炎作用，其作用机制是抑制环氧化酶活性阻断前列腺素合成。前列腺素是某些眼内炎症的介质，可致血-房水屏障崩溃、血管扩张、血管通透性增加、白细胞趋化，引起与胆碱能机制无关的瞳孔缩小。临床研究表明，本品可抑制白内障手术时的瞳孔缩小，对眼内压无明显影响。非临床毒理研究 在小鼠或大鼠的长期研究中，没有发现氟比洛芬有致癌性及导致不育症。长期的致突变研究尚未进行。

药代动力学
人眼滴入0.03%氟比洛芬钠50ml后30分钟，在房水中可检测到药物，2小时达到峰值(60ng/ml)；平均滞留时间约3.7小时。

适应症
用于术后抗炎，治疗激光小梁成形术后的炎症反应和其他眼前段炎症。预防和治疗白内障人工晶状体植入术后的黄斑囊样水肿。也用于治疗巨乳头性结膜炎。抑制内眼手术中的瞳孔缩小。

用法用量
抑制内眼手术时的瞳孔缩小 术前2小时开始滴眼，每半小时点1滴，共4次。消炎和术后消炎 一日3～4次，一次1滴；用药2～3周。激光小梁成形术后 一日3～4次，一次1滴；用药1～2周。

不良反应
有短暂烧灼、刺痛或其他轻微刺激症状。

禁忌
对本品过敏者禁用。

注意事项
（1）该药可能影响血小板凝聚而延长出血时间，因此有出血倾向或服用其他使出血时间延长药物者要慎用。
（2）该药可能与乙酰水杨酸或其他非甾体消炎药存在交叉过敏，因此，对这些药物过敏者应慎用。
（3）急性眼部感染疾病在局部使用抗炎药时，可能掩盖病情。
（4）本品无抗菌作用，对眼部感染性疾病，应同时应用抗生素。
（5）有单纯疱疹病毒性角膜炎病史者，慎用本药。

孕妇及哺乳期妇女用药
已经发现，给大鼠每天口服氟比洛芬0.4mg/kg以上（约相当于人每日局部用量的67倍）时，可引起胚胎损害、分娩延长、妊娠延长、体重下降、胎儿生长轻度受阻。但尚无人体研究报道，因此孕妇应慎用。尚不清楚氟比洛芬是否可通过母乳分泌，考虑到许多药物可经乳汁分泌，而且氟比洛芬对哺乳期婴儿有严重不良反应，因此，或停止哺乳或停止用药，须选择其一。

儿童用药
本药对儿童的安全性和疗效尚未考察。

药物相互作用
虽然临床及动物实验显示氟比洛芬与氯化乙酰胆碱及卡巴胆碱无相互影响，也无相互影响的药理基础，但有报告指出，外科病人在使用氟比洛芬时氯化乙酰胆碱及卡巴胆碱失去作用。

药物过量
过量使用通常不引起急症，意外食入可饮水稀释。

贮藏
贮存于15～25℃，远离儿童存放。

GENERIC NAME: FLURBIPROFEN - OPHTHALMIC (flewr-BIH-pro-fen)

BRAND NAME(S): Ocufen

USES: This medication is used before certain types of eye surgery (such as cataract removal). It prevents the pupil of the eye from narrowing. This effect makes it easier for the doctor to examine the inside of the eye, to remove the cataract, and to replace it with a new lens. Flurbiprofen belongs to a class of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs).OTHER This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.This medication may also be used after eye surgery to treat pain, swelling, and redness.

HOW TO USE: Apply the eye drops before surgery to the affected eye, usually every 30 minutes starting 2 hours before surgery (for a total of 4 drops), or as directed by your doctor. If you are directed to use this medication after eye surgery, follow your doctor's instructions.Do not wear contact lenses while you are using this medicine. Sterilize contact lenses according to the manufacturer's directions, and check with your doctor before you begin using them again.To apply eye drops, wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface.Tilt your head back, look upward, and pull down the lower eyelid to make a pouch. Hold the dropper directly over your eye and place 1 drop into the pouch. Look downward and gently close your eyes for 1 to 2 minutes. Place one finger at the corner of your eye (near the nose) and apply gentle pressure. This will prevent the medication from draining out. Try not to blink and do not rub your eye.Do not rinse the dropper. Replace the dropper cap after each use.If you are using another kind of eye medication (for example, other drops or ointments), wait at least 5 to 10 minutes before applying other medications. Use eye drops before eye ointments to allow the drops to enter the eye.This medication is intended for short-term use only. Do not use this medication more often or for longer than prescribed because doing so may increase your risk of serious side effects.Do not use this product if it becomes contaminated (for example, drops turn cloudy or a dark color). Use of contaminated eye medication can cause infection, serious damage to the eye, and loss of vision. Contact your doctor or pharmacist for more information.If you are instructed to use this medication after eye surgery, tell your doctor if your symptoms persist or worsen.

SIDE EFFECTS: Stinging/burning of the eyes for 1 to 2 minutes may occur when you apply this medication. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these rare but serious side effects occur: eye pain, decreased vision, bleeding in the eye (increased redness in the eye).A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using flurbiprofen, tell your doctor or pharmacist if you are allergic to it; or to aspirin or other NSAIDs (such as ibuprofen, celecoxib); or if you have any other allergies. This product may contain inactive ingredients (such as preservatives like thimerosal), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: aspirin-sensitive asthma (a history of worsening breathing with runny/stuffy nose after taking aspirin or other NSAIDs), other types of asthma, growths in the nose (nasal polyps), bleeding or clotting problems, other eye problems (such as cornea problems, dry eye syndrome, past eye surgeries), diabetes, rheumatoid arthritis.Your vision may be temporarily blurred or unstable after applying eye drops. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).During pregnancy, this medication should be used only when clearly needed during the first 6 months. It is not recommended for use during the last 3 months of pregnancy due to possible harm to an unborn baby. Discuss the risks and benefits with your doctor.It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: The effects of some drugs can change if you take other drugs or herbal products at the same time. This can increase your risk for serious side effects or may cause your medications not to work correctly. These drug interactions are possible, but do not always occur. Your doctor or pharmacist can often prevent or manage interactions by changing how you use your medications or by close monitoring.To help your doctor and pharmacist give you the best care, be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before starting treatment with this product. While using this product, do not start, stop, or change the dosage of any other medicines you are using without your doctor's approval.Some products that may interact with this drug include: drugs that can cause bleeding (antiplatelet drugs such as clopidogrel, "blood thinners" such as warfarin/heparin).Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (aspirin, NSAIDs such as ibuprofen/naproxen) which, if used together with flurbiprofen, may increase your risk of bleeding. However, if your doctor has directed you to take low-dose aspirin for heart attack or stroke prevention (usually at dosages of 81-325 milligrams a day), you should continue taking it unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details.This document does not contain all possible drug interactions. Keep a list of all the products you use. Share this list with your doctor and pharmacist to lessen your risk for serious medication problems.

OVERDOSE: This medicine may be harmful if swallowed. If overdose or swallowing is suspected, contact your local poison control center or emergency room immediately. US residents can call the US National Poison Hotline at 1-800-222-1222. Canada residents can call a provincial poison control center.

NOTES: Do not share this medication with others.This medication has been prescribed for your current condition only. Do not use it later for another eye condition unless told to do so by your doctor. A different medication may be necessary in that case.

MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

STORAGE: Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light. Do not store in the bathroom. Keep the bottle tightly closed when not in use. Keep all medicines away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

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 详细处方信息以本药内容附件PDF文件（20127318261339.PDF）的“原文Priscribing Information”为准
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