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  药店国别: 美国药房
产地国家: 美国
所属类别: 影响血液及造血系统药物->溶栓抗凝药物
处方药:处方药
包装规格: 5毫克/瓶
计价单位:
  点击放大  
生产厂家中文参考译名:
百时美施贵宝
生产厂家英文名:
BRISTOL MYERS SQUIBB
该药品相关信息网址1:
http://www.coumadin.com/
该药品相关信息网址2:
http://www.drugs.com/coumadin.html
该药品相关信息网址3:
http://www.rxlist.com/coumadin-drug.htm
原产地英文商品名:
COUMADIN 5mg/bottle
原产地英文药品名:
WARFARIN SODIUM
中文参考商品译名:
可密定 5毫克/瓶
中文参考药品译名:
华法林钠
中文参考化合物名称:
3-(3-氧代-1-苯基丁基)-4-羟基-2H-1-苯并吡喃二酮钠盐与异丙醇的包含物
原产地国家批准上市年份:
1954/06/08
英文适应病症1:
Venous thrombosis
英文适应病症2:
Pulmonary embolism
英文适应病症3:
Thrombosis
临床试验期:
完成
中文适应病症参考翻译1:
静脉血栓
中文适应病症参考翻译2:
肺栓塞
中文适应病症参考翻译3:
血栓
药品信息:

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 详细处方信息以本药内容附件PDF文件(200943004144712.pdf)的“原文Priscribing Information”为准
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部分中文华法林钠处方资料(仅供参考)

COUMADIN® (Warfarin Sodium) is used to help prevent and treat blood clots in the legs, lungs, and those clots associated with heart-valve replacement or an irregular, rapid heartbeat called atrial fibrillation.
If you have had a heart attack, COUMADIN may be used to lower the risk of death, another heart attack, stroke, and blood clots moving to other parts of the body.
IMPORTANT SAFETY INFORMATION:
COUMADIN can cause serious and life-threatening bleeding. Bleeding is more likely to occur when you first start taking COUMADIN and with a higher dose.
Factors that can increase your risk of bleeding while on COUMADIN therapy include being 65 years of age or older, an INR greater than 4, highly variable INRs, history of bleeding involving the stomach or intestine, high blood pressure, certain diseases of the brain, heart or kidney, anemia, cancer, physical injury, taking other drugs, and a long duration of therapy.
The PT/INR test checks to see how fast your blood clots. Your healthcare provider will decide what PT/INR numbers are best for you. Your dose of COUMADIN will be adjusted to keep your PT/INR in a target range for you.
Tell your healthcare provider right away if you have any signs or symptoms of bleeding problems such as the following: pain, swelling or discomfort, headache, dizziness, or weakness, unusual bruising, nosebleeds, bleeding of gums, bleeding from cuts that take a long time to stop, menstrual flow or vaginal bleeding that is heavier than normal, pink or brown urine, red or black stools, coughing up blood, or vomiting blood or material that looks like coffee grinds.
Do not take COUMADIN (Warfarin Sodium) if you are pregnant or plan to become pregnant. COUMADIN can cause death or birth defects to an unborn baby. Use effective birth control if you can get pregnant.
Speak to your healthcare provider before breast-feeding while taking COUMADIN.
Tell your healthcare provider about all the medical conditions you may have, including recent or planned surgeries or medical or dental procedures.
Unsupervised patients with declining mental function due to aging or mental illness, and patients with alcoholism or increased risk of bleeding should not take COUMADIN.
Death of skin tissue (skin necrosis or gangrene) is a serious, side effect of COUMADIN. It happens because blood clots form and block blood flow to an area of your body. Call your healthcare provider right away if you have pain, color, or temperature change to any area of your body. You may need medical care right away to prevent death or loss (amputation) of your affected body part.
Call your healthcare provider right away if you have pain in your toes and they look purple or dark in color. You may be experiencing a serious condition known as purple toes syndrome.
Many factors alone or together such as changes in diet and medicines, including herbal supplements, may affect your response to COUMADIN. Tell your healthcare provider about your diet, all prescription and non-prescription medicines, vitamins, and herbal products you are taking or plan to take. Speak with your healthcare provider before starting, changing, or stopping any of these products. Many drugs, including aspirin and other pain medicines, may interact with COUMADIN (Warfarin Sodium). Eat a normal balanced diet. Do not make changes in your diet, such as eating large amounts of leafy green vegetables, which contain Vitamin K without first talking to your healthcare provider.
Avoid alcohol consumption, cranberry juice, and cranberry products while taking COUMADIN.
Tell your doctor if you have any illness such as diarrhea, infection or fever.
Be aware that COUMADIN and generic warfarin tablets represent the same medication and should not be taken together, as overdosage may result.
If you take too much or miss a dose of COUMADIN, call your healthcare provider. Take the missed dose as soon as possible on the same day. Do not take a double dose of COUMADIN the next day to make up for a missed dose.
If you have any other questions about COUMADIN (Warfarin Sodium) and your condition, contact your healthcare provider.

【药物名称】可密定 Coumadin
【药理毒理】为香豆素类口服抗凝血药,竞争性拮抗维生素K的作用可阻断lit K环氧化物转变为氢醌形式。
【适 应 证】预防和/或治疗静脉血栓的形成及扩展,肺栓塞;预防和/或治疗房颤和/或心脏瓣膜置换后引起的血栓栓塞并发症;减少心肌梗塞后死亡率、复发率和血栓栓塞并发症如卒中或体循环栓塞
【不良反应】组织器官出血,根据出血的部位和程度不同的表现;皮肤或其它组织的坏死;其它少见的不良反应如:过敏反应、紫癜、皮疹、水肿、皮炎、腹痛、昏睡、不适、恶心、呕吐、头痛等。
【用法用量】可密定属治疗窗较小药物,其剂量和给药必须根据病人的PT或INR(国际标准化比值)而个体化给药。除置换有机械性瓣膜的病人INR应控制在2.5-3.5,其余情况INR应控制在2.0-3.0。
用药要从小剂量开始,一般为每天2~3mg(老年人应略低),然后根据PT或INR值调整剂量,疗程一般到血栓形成或血栓的危险消失。
【注意事项】用抗凝治疗后任何局部或全身的出血危险性大于治疗所得到的临床受益情况都视为禁忌症。如:妊娠妇女服用时,可密定可通过胎盘屏障,引起宫内胎儿出血或畸形;出血倾向或血质不调;近期有手术情况,特别是中枢神经系统、眼和其他创伤性手术;活动性溃疡或其他组织隐性出血倾向;消化道、泌尿生殖道和呼吸道‘脑血管;动脉瘤;心包炎心包积液和细菌性心内膜炎等;先兆流产、子痫或先兆子痫;无人照顾的老年病人,酗酒者,精神病和其他不合作病人;脊髓穿刺和其他可引起出血的诊断和治疗措施;其他大面积区域麻醉或腰部阻滞麻醉、恶性高血压和对香豆类药过敏者等。在长期应用最低维持量期间,如需手术,可先静脉注lit K,50mg,进行中枢神经系统或眼科手术前,应先停药。胃肠手术后,应检查大便隐血。

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 详细处方信息以本药内容附件PDF文件(200943004144712.pdf)的“原文Priscribing Information”为准
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更新日期: 2012-6-1
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