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 详细处方信息以本药内容附件PDF文件（20123117255934.PDF,20123117245311.PDF,20123117244613.PDF）的“原文Priscribing Information”为准
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部分中文Nuromol处方资料（仅供参考）

IBUPROFEN布洛芬（异布洛芬）
<<药物作用>>
    本药为一种「非固醇类止痛及抗发炎」药物。其主要的作用，就是能阻止体内「前列腺素」的产生，此一化学物质通常是造成关节疼痛以及发炎肿胀的主因，它可以解除风湿性关节炎，以及骨关节炎所引起的关节僵硬、疼痛、发炎、发肿的现象。此药同时可以解除多种轻微到中度的疼痛，如头痛、牙疼、月经痛，以及肌肉扭伤所引起的疼痛等。此药同时有退烧的作用，可使体温降到正常程度。

<<用法>>
    为了减轻对胃的刺激，此药最好与食物或饭後服用，并饮用一杯水(约250 CC)。在服完药後15至30分钟内，最好不要立即躺下，以免药物对上消化道直接刺激。如有必要时，此药的药片可以压碎服用。如果是使用液体药物时，每次在使用前，应先将药瓶轻微摇动，使药物能均匀分散，并使用有刻度的量杯或药管，以量取正确的药量。

<<注意事项>>
    服用此药後，可能会产生轻微头晕目眩及视觉模糊现象，并且可能会有疲乏的感觉。因此，在尚未适应此药之前，当开车或操作危险机械时，应该格外地小心谨慎。
    如果怀孕或哺乳婴儿，对药物过敏，或者有血液凝固力面的问题、肝脏疾病、红斑性狼疮、胃出血、胃溃疡、气喘病、高血压、充血性心衰竭、肾脏病、糖尿病等等，医师需要针对这些情况谨慎用药，使用此药前，应该先通知医师。
    长期服用此药对胃的刺激非常大，应该随时留意是否有胃出血或胃溃疡发生。如果有暗黑色条纹或块状的粪便时，此为内出血的徵兆，应该通知医师做进一步的检查。
    服用阿斯匹灵或酒精会增加此药对胃肠的刺激，应该尽量避免与此药合用。另外一些抗关节炎药物，或者抗凝血剂也会增加胃肠的刺激作用、降低血液凝固的能力，如果长期与此药合用，有造成胃出血的可能。因此同时使用这些药物时，应该得到医师的许可。
    如果服用此药的目的是要退烧，当使用此药超过3天，而体温还不能降低的话，就应该通知医师。如果服用此药是为止痛，当服用此药超过10天(小孩5天)，而疼痛仍然不能消除时，也应该通知医师。　
    如果服用此药的目的在治疗关节炎，通常在服药後的一个星期内，四肢关节的症状，应该有所改善。但是通常此药至少必须经过两三个星期，才能达到最大的作用。另外，由於此药只能改善关节炎的症状，并不能治愈，必须长期按时服用，才能达到最好的效果，也不能因为一时觉得症状已经改善而停止服药。
    此药会抑制血液的凝固使流血的时间增长，在拔牙或动手术之前，应该先通知医师，通常在手术前几天，医师会要求停止服用此药，以免手术进行当中造成过量流血的现象。
    此药有可能会增加水分在体内的滞留，间接地使血压升高，或增加心脏病患者心脏的工作量。因此应该随时留意四肢，如果发现有肿胀时，就应该通知医师。
    老年人对此药所引起的胃肠副作用较一般人敏感;同时，由於老年人的肾脏功能较一般人为差，药物经由肾脏排出体外的能力也相对地降低，最後可能会导致药物积聚而引起肾脏及肝脏的毒性。医师可能会要求此类病人服用较一般人为低的剂量，甚至到减半的程度。使用此药时，应该完全遵照医师指示的剂量服用。

<<副作用>>
    Ibuprofen最常见的副作用为：胃灼热（3％至9％），恶心（3％至9％），呕吐（口服，1％至 3％;）头晕（3％至9％），头痛（1％至3％）。其它可能副作用包括：便秘、腹泻、腹胀气、神经紧张、耳鸣等等。这些现象通常在服用药物一阵子後，会渐渐消失;不过，如果强到困扰你的程度，或者经过一时间後，还不能完全消除，就应该通知医师。
    此药较严重的副作用为:心跳不正常、皮肤起红疹或发痒、吐血或含暗黑色的物质、含有带黑色的粪便、呼吸困难、气喘、胸痛、发热、发冷及喉咙酸痛、腹痛或胃痛、严重的头痛等。通常这些副作用发生的机率较低，但是如果发生时，可能是药物造成的不良反应，或者是剂量需要调整，应该尽快通知医师。

<<怀孕及哺乳>>
    美国药管局(FDA)将此药在怀孕第一、二期 (前六个月)归类为怀孕类别C级：C级表示动物繁殖研究显示药物对胎儿有不利影响、但没有对人类孕妇所做对照组研究。尽管有潜在风险、但在潜在利益大於潜在危险前提下、仍然可以考虑使用。
  美国药管局(FDA)将此药在怀孕第三期 (後三个月)归类为D级：D级表示从以往研究或销售经验中、已有足够证据显示药物会对胎儿产生危险性。尽管有潜在风险、但在用药利益大於危险性无的前提下、仍然可以考虑使用。
    目前尚无资料显示此药会造成胎儿生长缺陷，但是怀孕妇女最好不要服用此药。孕妇於怀孕後期尤其是最後三个月服用此药的话，可能会造成胎儿心脏血管及血液凝结方面的问题。同时，此药可能会增长孕妇怀孕、生产的时间和其他生产过程中的问题。
    少量的药物会经由母乳到达新生儿体内，可能会造成新生儿血液循环及心脏血管方面的问题。喂奶的母亲应该考虑使用其他乳制品以取代母乳。

<<忘记用药>>
    如果忘记服药，应该在记得时，立即服用。但是，如果一天服药两次以上，而下次服药的时间少於4小时，就应该舍弃此次药物，恢复到下次正常服药的时间，不可以一次服用双倍的剂量。

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对乙酰氨基酚片(Paracetamol,扑热息痛)
【中文品名】对乙酰氨基酚

【药效类别】解热镇痛药

【通用药名】ACETAMINOPHEN

【别　　名】Paracetamol, Excedrin, Migraine, Tylenol, Ultracet

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Nuromol (24 Tablets) [P]
Nuromol combines ibuprofen and paracetamol in one tablet for double action pain relief in headache, migraine, back pain, period pain, dental pain etc.

Product Info
Nuromol contains two active ingredients (which make the medicine work). These are Ibuprofen and Paracetamol.

Ibuprofen belongs to a group of medicines known as non-steroidal anti-inflammatory drugs (NSAIDs). NSAIDs work by reducing pain, reducing swelling and lowering high temperatures.

Paracetamol is an analgesic which works in a different way from ibuprofen to relieve pain and fever. Nuromol is used for the temporary relief of mild to moderate pain associated with migraine, headache, backache, period pain, dental pain, rheumatic and muscular pain, pain of non-serious arthritis, cold and flu symptoms, sore throat and fever.

Directions
Nuromol is for oral use and for short term use only.

Only use the minimum effective dose for the shortest time necessary to relieve your symptoms.

You should not take Nuromol for longer than 3 days. If your symptoms worsen or persist, consult your doctor.

Take 1 tablet with water and food, up to 3 times a day. Leave at least 6 hours between doses.

If one tablet does not control symptoms, then a maximum of 2 tablets may be taken up to three times o day. Do not take more than six tablets in any 24 hour period (equivalent to 3000mg Paracetamol, 1200mg Ibuprofen a day).

Not for use by children under 18 years.

If you take more Nuromol than you should
Immediate medical advice should be sought in the event of an overdose, even if you feel well, because of the risk of delayed, serious liver damage.

If you forget to take Nuromol
Do not take a double dose to make up fora forgotten dose. If you forget to take o dose, take it as soon as you remember it and then take the next dose at least 6 hours later.

Contents
What Nuromol contains.

The active substances are ibuprofen and paracetamol. Each film-coated tablet contains 200 mg of ibuprofen and 500 mg of paracetamol

The other ingredients are croscarmellose sodium, microcrystalline cellulose, colloidal anhydrous silica, magnesium stearate, stearic acid. Film coating: polyvinyl alcohol, titanium dioxide, talc, macrogol, potassium aluminium silicate (E555), polysorbate.

Warmings
Before You Take Nuromol
Do not take Nuromol if you
•are already taking any other paracetamol containing product.
•are taking any other pain relieving products including ibuprofen, high dose aspirin (above 75mg per day), or other non-steroidal anti inflammatory drugs (NSAIDs) including cyclo-oxygenase-2 (COX-2) specific inhibitors
•are allergic to ibuprofen, paracetamol or any other ingredients in Nuromol
•are allergic to aspirin or other NSAID painkillers
•have or ever had an ulcer or bleeding in your stomach or duodenum (small bowel)
•have blood clotting (coagulation) disorder
•suffer from heart, liver or kidney failure
•are in the last 3 months of pregnancy
•are under 18 years old.

Take special care and check with a doctor or pharmacist before taking Nuromol if you
•are elderly
•have asthma or have suffered from asthma
•have kidney, heart, liver or bowel problems
•have Systemic Lupus Erythematosus (SLE) - a condition of the immune system affecting connective tissue resulting in joint pain, skin changes and disorder of other organs or other mixed connective tissue disease
•have gastrointestinal disorders or chronic inflammatory bowel disease (e.g. ulcerative colitis, Crohn's disease
•are in the first 6 months of pregnancy or are breastfeeding
•are planning to become pregnant.

If you have heart problems, previously had a stroke or think that you might be at risk of these conditions; (for example if you have high blood pressure, diabetes or high cholesterol or are a smoker), you should discuss your treatment with your doctor or pharmacist.

Taking Nuromol with food
To reduce the likelihood of side effects, take Nuromol with food.

Pregnancy and breastfeeding
Ask your doctor or pharmacist for advice before taking any medicine. Do not take if you are in the last 3 months of your pregnancy. Take special care if you are in the first 6 months of pregnancy.
Nuromol may make it more difficult to become pregnant. Ibuprofen belongs to a group of medicines which may impair fertility in women. This is reversible on stopping the medicine. You should inform your doctor if you are planning to become pregnant or it you have problems becoming pregnant.

Taking Nuromol With Other Medicines
Do not take Nuromol with
•other paracetamol containing products
•other NSAID containing products such as aspirin, ibuprofen.

Special care is required as some medicines may interact with Nuromol, for example:
•corticosteroid tablets
•antibiotics (e.g. chloramphenicol or quinolones) • anti sickness medicines (e.g. metoclopramide, domperidone)
•medicines to thin the blood or prevent clotting {e.g. warfarin)
•heart stimulants(e.g. glycosides)
•medicines for high cholesterol (e.g. cholestyramine)
•diuretics (to help you pass water)
•medicines for high blood pressure
•medicines to suppress the immune system (e.g. methotrexate, ciclosporine, tacrolimus)
•medicines for manta or depression (e.g. lithium or SSRls)
•mifepristone (for pregnancy termination)
•HIV medicines (e.g. zidovudine).

Always seek the advice of your doctor or pharmacist before you take Nuromol with other medicines.

Possible Side Effects
Like all medicines, Nuromol can cause side effects, although not everybody gets them.

STOP TAKING the medicine and tell your doctor if you experience:
•heartburn, indigestion
•signs of intestinal bleeding (severe stomach pain, vomiting blood or liquid with what looks like coffee granules, blood in the stools/motions, black tarry stools)
•signs of inflammation of the brain lining such as: stiff neck, headache, feeling or being sick, fever or feeling disorientated
•signs of a severe allergic reaction (swelling of the face, tongue or throat, difficult breathing, worsening of asthma).

Other possible side effects
Common (occurs in less than 1 in 10 people):
•stomach pain or discomfort, feeling or being sick, diarrhoea,
•higher levels of liver enzymes (shown in blood tests)

Uncommon (occurs in less than 1 in 100 people):
•headache and dizziness, wind and constipation, skin rashes, swelling of the face
•Reduction in red blood cells number or increase in platelets (blood clotting cells) number.

Very rare (occurs in less than 1 in 10,000 people):
•reduction in blood cells (causing sore throat, mouth ulcers, flu-like symptoms, severe exhaustion, unexplained bleeding, bruising and nosebleeds)
•visual disturbances, ringing in the ears, spinning sensation
•confusion, depression, hallucinations
•fatigue, generally feeling unwell
•severe skin reactions such as blistering
•high blood pressure, water retention
•liver problems (causing yellowing of the skin and white of eyes)
•kidney problems (causing increased or decreased urination, swelling of the legs)
•heart failure (causing breathlessness, swelling). Medicines such as Nuromol may be associated with a small increased risk of heart attack ("myocardial infarction") or stroke.

If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

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 详细处方信息以本药内容附件PDF文件（20123117255934.PDF,20123117245311.PDF,20123117244613.PDF）的“原文Priscribing Information”为准
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