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  药店国别: 美国药房
产地国家: 美国
所属类别: 神经系统药物->头痛药物
处方药:处方药
包装规格: 5毫克/片 18片/盒
计价单位:
  点击放大  
生产厂家中文参考译名:
默克
生产厂家英文名:
MERCK
该药品相关信息网址1:
http://www.maxalt.com/
该药品相关信息网址2:
http://www.drugs.com/maxalt.html
该药品相关信息网址3:
http://www.rxlist.com/maxalt-drug.htm
原产地英文商品名:
MAXALT 5MG/TAB 18TABS/BOX
原产地英文药品名:
RIZATRIPTAN BENZOATE
中文参考商品译名:
MAXALT 5毫克/片 18片/盒
中文参考药品译名:
苯甲酸利扎曲普坦
原产地国家批准上市年份:
1998/06/29
英文适应病症1:
Migraine
临床试验期:
完成
中文适应病症参考翻译1:
偏头痛
药品信息:

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 详细处方信息以本药内容附件PDF文件(2011121423084539.pdf)的“原文Priscribing Information”为准
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部分中文利扎曲坦处方资料(仅供参考)

英文药名: Maxalt (Rizatriptan Tablets)

中文药名: 利扎曲坦片

药品名称
产品名称: 苯甲酸利扎曲普坦
英文名称: Rizatriptan Monobenzoate
用途分类: 神经系统类/偏头痛
主要成份: 苯甲酸利扎曲普坦

药品简介
利扎曲坦(rizatriptan,maxalt),系美国默克公司研制,1998年10月在荷 兰首次上市的第4个获准上市的曲坦类药物。本品口服剂型生利用度约40%,而作用达峰时短至1小时,故起效快,给药后30分钟即可见13%-28%的患者症状明显改善。本品剂型有常规口服片和速溶片两种,剂量规格有5 mg和10 mg两种。

适应症
用于成人有或无先兆的偏头痛发作的急性治疗,不适用于预防偏头痛,不适用于半身不遂或基底部偏头痛患者。

用法用量
口服给药, 一次5-10mg(1-2粒),每次用药的时间间隔至少为2小时,一日最高剂量不得超过30mg(6粒),或遵医嘱。

不良反应
本品有很好的耐受性,不良反应轻且时间短暂,主要副作用是虚弱,易疲劳,嗜睡,有疼痛或压迫感及眩晕。严重的心脏意外,包括在使用5?HT1激动剂后出现死亡,这些事件极少发生。报道的病人多伴有冠状动脉疾病(CAD)危险因素先兆,意外事件有冠状动脉痉挛,短暂性心肌缺血,心肌梗死,室性心动过速及室颤。

禁忌症
1. 禁用于局部缺血性心脏并(如:心绞痛 心肌梗死或有记录的无症状缺血)的患者。
2. 禁用于有缺血性心脏病,冠状动脉痉挛(包括Prinzmetal变异型狭心症或其他隐性心血管疾病等)症状,体征的患者。
3. 因本品能升高血压,故不易控制血压的高血压患者禁用。
4. 禁用于半身不遂或基底部偏头痛患者。
5. 禁止同时服用MAO抑制剂,禁止在停服MAO抑制剂两周内服用本品。
6. 对本品或任一活性成分过敏者禁用。
7. 在服用本品治疗的24小时内,禁止服用其他5-HT1激动剂,含有麦角胺或麦角类药物如双氢麦角胺,美西麦角等。

药物相互作用
1. 由于普萘洛尔可使本品的血浆浓度增加70% 可在服用普萘洛尔同时服用本品5mg。
2. 含麦角的药物能延长血管痉挛反应,在服用本品24小时内不可同时服用含有麦角胺或麦角胺型药物(如双氢麦角胺 美西麦角)。
3. 其他5-HT1激动剂可以累积血管痉挛的作用,不推荐在24小时内联合服用本品和其他5-HT1激动剂。
4. 如果临床有正当理由准许本品与选择性5-羟色胺再吸收抑制剂(SSRLs)合用,应注意对病人进行严密观察。
5. 本品10mg与帕罗西汀同时服用后没有发现两者在临床或药理方面的相互作用。
6. 本品不能与MAO-A抑制剂,非选择性MAO抑制剂合用。

Maxalt
Generic Name: rizatriptan (RYE za TRIP tan)
Brand Names: Maxalt, Maxalt-MLT

What is Maxalt?
Maxalt is used to treat migraine attacks in adults. It shortens the duration of the headache but will not prevent attacks. Maxalt is available as a regular tablet and an orally disintegrating tablet (Maxalt-MLT).

What is the most important information I should know about Maxalt?
Maxalt should only be used during a migraine attack. Do not attempt to prevent migraines with this drug, and do not use it for other types of headaches.

In rare cases, medications similar to Maxalt have caused heart attack, stroke, and certain types of ischemia (restricted blood flow to an area). Call your doctor immediately if you experience chest pain, shortness of breath, sudden numbness or weakness on one side of the body, trouble speaking or seeing, loss of balance, bloody diarrhea, or stomach pain.

If you are at risk for stroke or heart disease, your doctor may perform cardiovascular tests to be sure it is safe for you to take this medication. Maxalt can also increase blood pressure, especially in people with kidney problems and the elderly. Your doctor will monitor you closely to make sure your blood pressure stays at a safe level.

Who should not take Maxalt?
Do not take Maxalt if you are allergic to it or any of its ingredients, or if you have a history of heart disease or uncontrolled high blood pressure. Do not take Maxalt with monoamine oxidase (MAO) inhibitors, a class of drugs used to treat depression and other psychiatric conditions.

What should I tell my doctor before I take the first dose of Maxalt?
Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Maxalt. Also, talk to your doctor about your complete medical history, especially if you have a history of kidney or liver problems, high blood pressure, stroke or blood vessel disease, heart problems, or if you have risk factors for heart disease (such as high cholesterol, diabetes, smoking, obesity, or a family history of heart disease or stroke). Also tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.

What is the usual dosage?
The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

Adults: The usual dose to treat an attack is one tablet containing either 5 milligrams (mg) or 10 mg; each dose should be separated by at least 2 hours. Do not take more than 30 mg of Maxalt in a 24-hour period.

How should I take Maxalt?
Take Maxalt as soon as you feel a migraine starting, exactly as prescribed by your doctor. If your headache comes back after your first dose, you may take a second dose 2 or more hours after the first dose.

Swallow Maxalt tablets whole with liquid. For the orally disintegrating tablets (Maxalt-MLT), open the blister pack with dry hands and place the tablet on your tongue; it will dissolve rapidly and be swallowed with your saliva. You do not need to take any liquid after the tablet dissolves.

What should I avoid while taking Maxalt?
Since Maxalt can make you drowsy or dizzy, do not participate in activities that require full alertness until you know how this drug affects you.

What are possible food and drug interactions associated with Maxalt?
If Maxalt is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Maxalt with propranolol. Do not take Maxalt within 2 weeks of starting or stopping certain antidepressants and Parkinson's drugs known as MAO inhibitors.

Do not take Maxalt within 24 hours of using another migraine or headache drug, including triptans and ergotamines such as the following: almotriptan, dihydroergotamine, ergotamine, frovatriptan, methysergide, naratriptan, rizatriptan, sumatriptan, and zolmitriptan.

What are the possible side effects of Maxalt?
Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

Side effects may include: dizziness, sleepiness, tiredness, fatigue, pain or pressure in the chest or throat, dry mouth, nausea, headache, warm/cold sensations, palpitations, diarrhea, vomiting, tremor, difficulty breathing, flushing, hot flashes

Call your doctor immediately if you experience any of the following serious side effects: visual disturbances, ringing in the ears, ear pain, eye discomfort, alterations in hearing and smelling, intolerance to light, chills, heat sensitivity, swelling, fever, extreme dizziness, fainting after standing, dehydration, changes in urination or menstruation, and allergic reactions such as rash or itching.

Can I receive Maxalt if I am pregnant or breastfeeding?
The effects of Maxalt during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

What should I do if I miss a dose of Maxalt?
Maxalt is not intended for regular use and should be taken only to relieve an acute (sudden) migraine attack.

How should I store Maxalt?
Store at room temperature away from heat, light, and moisture. Keep Maxalt-MLT in the blister packet until you are ready to take the medication.

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 详细处方信息以本药内容附件PDF文件(2011121423084539.pdf)的“原文Priscribing Information”为准
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更新日期: 2011-12-15
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