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  药店国别: 英国药房
产地国家: 英国
所属类别: 神经系统药物->广泛性焦虑症
处方药:处方药
包装规格: 10毫克/片 30片/盒
计价单位:
  点击放大  
生产厂家中文参考译名:
赛诺菲
生产厂家英文名:
Sanofi
该药品相关信息网址1:
http://www.netdoctor.co.uk/medicines/100001097.html
该药品相关信息网址2:
http://chealth.canoe.ca/drug_info_details.asp?brand_name_id=359&rot=4
原产地英文商品名:
FRISIUM 10MG/TAB 30TABS/BOX
原产地英文药品名:
CLOBAZAM
中文参考商品译名:
服利宁 10毫克/片 30片/盒
中文参考药品译名:
氯巴占
原产地国家批准上市年份:
0000/00/00
英文适应病症1:
Anxiety
英文适应病症2:
Refractory epilepsy
临床试验期:
完成
中文适应病症参考翻译1:
焦虑症
中文适应病症参考翻译2:
难治性癫痫
药品信息:

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 详细处方信息以本药内容附件PDF文件(2011121317310837.pdf)的“原文Priscribing Information”为准
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部分中文氯巴占处方资料(仅供参考)

氯巴占
分类名称
一级分类:神经系统药物 二级分类:抗癫痫药物 三级分类:其他 
 
药品英文名
Clobazam
 
药品别名
氧异安定、氯巴扎姆、异安定酮、Frisium、Urbanol
 
药物剂型
片剂:10mg,20mg。
 
药理作用
本品为长效苯二氮卓类药物,药理作用与地西泮相似,其镇静副作用很小,更适合用于成人癫痫的辅助治疗。本品对不同病因引起的癫痫患者的部分性发作和全身性发作均有效,但通常作为辅助用药。对可预测癫痫发作的患者(例如妇女月经性癫痫)可采用间歇治疗。间歇方法有助于预防耐受性的产生。
 
药动学
口服易于吸收,1~4h可达血药峰值,85%与血浆蛋白结合。在肝内通过,脱甲基和羟基化作用进行代谢。原药和活性代谢物N-去甲基氯巴占的平均t1/2分别为18h和42h。本品高度亲脂,迅速透过血-脑脊液屏障。原药和代谢物主要随尿排出。
 
适应证
适用于焦虑症和难治性癫痫的治疗。对癫痫复杂性发作继发全身性发作和伦-加综合征效果更佳。
 
禁忌证
1.对本品过敏者、孕妇、哺乳者禁用。
2.严重肝病、急性闭角型青光眼和卟啉症患者禁用。
 
注意事项
如连续应用,其抗惊厥作用逐渐减弱,可采用“放假疗法”,如女性患者,在月经期发作时,可在月经来潮前2~3天开始用药,10天后再用。
 
不良反应
1.参见地西泮。
2.偶有焦躁、抑郁和肌无力。
3.偶有月经性癫痫患者服药后经期推迟的报道。
4.突然停药可出现戒断症状,亦可加剧癫痫发作,故停药应逐渐减量过渡。
5.个例报道,本品可致中毒性表皮坏死松解症。
 
用法用量
1.治疗焦虑症:常用每天20~30mg,分次服,或单次晚间服。
2.用于癫痫的辅助治疗:剂量与用法同治疗焦虑症。
3.3岁或大于3岁儿童:推荐剂量为不超过成人剂量的1/2。
4.老年或体弱患者的推荐剂量为每天10~20mg。
 
药物相应作用
1.参见地西泮。
2.与卡马西平、苯巴比妥、苯妥英钠、丙戊酸合用,本品的血浓度降低,而后者浓度升高。
 
专家点评
该药为广谱抗癫痫药物。但因其抗癫痫机制同氯硝西泮,除出现困倦等副作用外可产生药物依赖性。

Frisium(clobazam)
DIN (Drug Identification Number)
02221799  FRISIUM 10MG TABLET

How does Frisium work? What will it do for me?
Clobazam belongs to the class of medications known as benzodiazepines. It is used to treat certain seizure disorders. It is used as an add-on to other antiseizure medications when extra treatment for control of seizures is needed.

Seizures are caused by uncontrolled firing of neurons in the brain (also referred to as increased electrical activity in the brain). This medication works by reducing the rate of firing of these neurons.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

How should I use Frisium?
The recommended adult dose of clobazam ranges from 5 mg to 80 mg daily, as directed by your doctor, taken in 1 or 2 doses with or without food. Doses up to 30 mg daily may be taken as a single daily dose. Higher doses must be split into 2 daily doses. The dose is usually started at 5 mg to 15 mg daily and increased gradually as needed. For children 2 to 16 years, the starting dose should be 5 mg daily, increased gradually to a maximum of 40 mg per day. For children younger than 2 years, the starting dose is based on body weight. If you have reduced liver or kidney function, your doctor may recommend a lower dose.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

What form(s) does Frisium come in?
Each white, uncoated, round tablet, scored on one side with "B" marked above the score line and "GL" below the score line, and the other side marked with a logo, contains clobazam 10 mg. Nonmedicinal ingredients: lactose, cornstarch, talc, colloidal silicon dioxide, and magnesium stearate.

Who should NOT take Frisium?
Do not take this medication if you:
•are allergic to clobazam or any ingredients of this medication
•are allergic to other benzodiazepines (e.g., diazepam, lorazepam)
•are breast-feeding
•are in the first 3 months of pregnancy
•have a history of drug or alcohol dependence
•have acute narrow-angle (closed-angle) glaucoma
•have myasthenia gravis
•have severe breathing problems or sleep apnea
•have severe liver impairment

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 详细处方信息以本药内容附件PDF文件(2011121317310837.pdf)的“原文Priscribing Information”为准
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更新日期: 2017-09-11
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