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 部分中文美他多辛处方资料（仅供参考）
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【中文品名】美他多辛

【药效类别】酒精中毒治疗药

【通用药名】METADOXINE

【别　　名】Metadoxil

【化学名称】 L-Proline 5-oxo-, compd. with 5-hydroxy-6-methyl-3,4-pyridinedimethanol (1:1)

【CA登记号】[74536-44-0]

【分 子 式】CHNOPS·

【开发单位】Baldacci

【首次上市】1985年，意大利

【用　　途】5-羟色胺拮抗剂，用于治疗酒精中毒。

【不同适应症和各年龄组别患者的用法用量】
口服给药
急性酒精中毒
成人: 500-1000 mg/天。
口服给药
酒精性脂肪肝
成人: 1000 mg/天。
口服给药
急性和慢性肝脏疾病的支持疗法
成人: 1000 mg/天。
肠道外给药
急性酒精中毒
成人: 300-600 mg/天，肌注/静注。
肠道外给药
酒精性脂肪肝
成人: 300 mg/天，肌注/静注。
肠道外给药
急性和慢性肝脏疾病的支持疗法
成人: 300 mg/天，肌注/静注。

【禁忌】妊娠及哺乳期禁用。

【药物相互作用】
降低左旋多巴的作用。给予左旋多巴/多巴脱羧酶抑制剂，会减弱这种相互作用。
严重药物相互作用: 降低左旋多巴的作用。给予左旋多巴/多巴脱羧酶抑制剂，会减弱这种相互作用。
 
【药理作用】美他多辛能促进酒精从血和组织中清除，使酒精中毒患者更快地恢复。在酒精性肝病的早期，美他多辛能防止肝细胞内氧化还原反应失衡，并能阻止肿瘤坏死因子介导的损伤。

【MIMS 药物分类】利胆剂、胆石溶解剂和保肝药 (Cholagogues, Cholelitholytics & Hepatic Protectors)

Viboliv (Metadoxine)
Main Use：Liver disease
Active Integredient：Metadoxine
Marketed Name：Viboliv®
 
Uses
Viboliv 500 (Metadoxine) is prescribed to patients who may have liver damage or fatty liver caused by either alcohol abuse or liver disease. It prevents further degeneration of the liver and therefore prevents more serious and possibly life threatening problems like hepatitis from occurring. It works by metabolizing the alcohol and other substances quicker and excreted them from the body faster.

Dosage and administration
Viboliv 500 (Metadoxine) should only be taken as prescribed. Correct dosage varies depending on the patient and on the severity of the condition being treated.

When used to treat liver damage caused by alcohol abuse the usual dosage is 500mg taken once a day. For chronic liver conditions such as liver disease or fatty liver, a common dosage is 500mg taken twice a day.

The maximum recommended dose for any 24 hours period is 1000mg.

Side effects
Viboliv 500 (Metadoxine) is usually well tolerated and any side effects are mild and short lasting. Side effects may still occur though, and your physician should be notified of any you notice. Pay special attention to your body so side effects can be picked up on early.

Seek medical attention immediately if you experience any skin rashes, diarrhea, hives, swelling, chest pains, trouble breathing, or difficulty swallowing. 

Precautions
Viboliv 500 (Metadoxine) is not suitable for patients who are pregnant, trying to conceive, or breastfeeding.

Prior to using this medication disclose any of the following to your prescribing physician:
Any allergies you suffer from
Any existing medical condition you suffer from
Any other medication you are taking (including all non-prescription medicine)
Any vitamins, supplements, or herbal products which you are using

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