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 详细处方信息以本药内容附件PDF文件（201151000080122.pdf）的“原文Priscribing Information”为准
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部分中文替可克肽处方资料（仅供参考）

中文品名：替可克肽

药效类别：促皮质素类合成多肽

通用药名：TETRACOSACTIDE

别　　名：Cosyntropin, Tetracosactrin

化学名称：α1-24-Corticotropin

分类名称
一级分类：内分泌系统药物 二级分类：下丘脑及影响内分泌的药物 

药物剂型
1.注射剂（Cortrosyn)：250μg(1ml)，供静脉注射和肌内注射用；
2.长效注射剂（Cortrosyn Depot)：1mg(1ml)，仅供肌内注射。
 
药理作用
本品作用与促肾上腺皮质激素相同，可刺激肾上腺皮质分泌皮质激素（主要是皮质醇)，因此对肾上腺皮质功能严重低下者无效。
 
药动学
为人工合成的24个氨基酸组成的多肽。其结构和促肾上腺皮质激素的第1个～第24个氨基酸相同。静脉给药可迅速升高血皮质醇水平，需维持血皮质醇浓度时应持续静脉点滴给药。肌内注射，血皮质醇于注射后1h达到高峰。以后可使升高的皮质醇维持约24h。
 
适应证
本品与促肾上腺皮质激素的作用相同。因此，其临床应用范围与促肾上腺皮激素相似。由于相同的用药指征多选用作用更强、副作用较小的皮质激素。因此，本品目前仅用于部分克罗恩病或溃疡性结肠炎和风湿性关节炎等少数疾病。长期应用皮质激素治疗的患者可联合使用本品，以预防肾上腺萎缩。本品和促肾上腺皮质激素一样也用于肾上腺皮质功能检查。但长效替可克肽一般不作为标准的肾上腺皮质功能试验用药。
 
禁忌证
不宜用于结核病、高血压、糖尿病、溃疡病和孕妇。
 
注意事项
（尚不明确)
 
不良反应
与促肾上腺皮质激素相同。大量使用可引起水钠潴留和高血压、精神异常、糖耐量异常、蛋白质消耗、骨质疏松、低血钾、月经异常、色素沉着和痤疮等。少数患者可对本品出现过敏反应，但发生率较促肾上腺皮质激素少。
 
用法用量
本品1mg相当于促肾上腺皮质激素100U，作为治疗用多采用本品的长效制剂。1.长效替可克肽成人的常用剂量是每天肌内注射1mg，当急性症状被控制后可减为每2～3天肌内注射1mg，稳定后可每2～3天肌内注射500μg，或每周肌内注射1mg。2.儿童的维持剂量是：2岁以内每2～8天250μg；5～12岁每2～8天为250μg～1mg。剂量应根据不同疾病以及个体的反应而定。
 
药物相应作用
（尚不明确)
 
专家点评
用于肾上腺皮质功能检查，正常人肌内注射或静脉注射本品250μg，30min或60min后的血皮质醇浓度不低于150μg/L（428nmol/L)，或较注射前增加50μg/L。如结果可疑，未能作出诊断时，可肌内注射长效24替可克肽1mg，正常人于注射后5h，血皮质醇浓度可逐渐升高至1000～1800nmol/L。
 
GENERIC NAME: COSYNTROPIN - INJECTION (koe-sin-TROW-pin)

BRAND NAME(S): Cortrosyn

USES: Cosyntropin is a man-made portion of a certain natural substance made by the body (ACTH). It is used to diagnose adrenal gland problems (e.g., Addison's disease, insufficiency due to corticosteroid use, pituitary tumor).

HOW TO USE: This medication is given by injection into a vein or muscle by a health care professional. Health care professionals must follow all the manufacturer's instructions for properly mixing and giving this drug. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. When this drug is given into a vein, it may be injected quickly (2 minutes) or mixed into a solution and given slowly (6 hours) as directed by your doctor.To test for your disease, your health care professional will usually do a blood test before giving this drug and then 30 minutes after your dose. Depending on the type of test your doctor is performing, he or she may require blood or urine samples at different times to measure your response to the test. Consult your doctor for details.

SIDE EFFECTS: Minor irritation at the injection site (e.g., redness, swelling) may occur. If any of these effects persist or worsen, tell your doctor.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using cosyntropin, tell your doctor or pharmacist if you are allergic to it; or to corticotropin; or if you have any other allergies.Before using this medication, tell your doctor or pharmacist your medical history.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: cortisone, estrogen, hydrocortisone, spironolactone, "water pills" (e.g., furosemide, hydrochlorothiazide).This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US National Poison Hotline at 1-800-222-1222. Canada residents can call a provincial poison control center.

NOTES: Blood/urine tests will be done to monitor your response. Consult your doctor for more details.

MISSED DOSE: Not applicable.

STORAGE: Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.After mixing, this product should be used immediately. Discard any unused portion of the vial.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

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 详细处方信息以本药内容附件PDF文件（201151000080122.pdf）的“原文Priscribing Information”为准
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