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  药店国别: 德国药房
产地国家: 德国
所属类别: 激素内分泌药物->抗雄激素
处方药:处方药
包装规格: 50毫克/片 56片/盒
计价单位:
   
生产厂家中文参考译名:
拜耳-先灵
生产厂家英文名:
Bayer Schering Pharma
该药品相关信息网址1:
http://en.wikipedia.org/wiki/Cyproterone
该药品相关信息网址2:
http://home.intekom.com/pharm/schering/androc50.html
该药品相关信息网址3:
http://www.netdoctor.co.uk/medicines/100000131.html
原产地英文商品名:
Androcur 50mg/tab 56tabs/box
原产地英文药品名:
cyproterone acetate
中文参考商品译名:
色普龙 50毫克/片 56片/盒
中文参考药品译名:
醋酸环丙孕酮
中文参考化合物名称:
6-氯-1α,2α-亚甲基-4,6-孕甾二烯-17α-羟基-3,20-二酮-17-醋酸酯
原产地国家批准上市年份:
0000/00/00
英文适应病症1:
Inoperable prostate cancer line anti-androgen therapy
临床试验期:
完成
中文适应病症参考翻译1:
对不能手术的前列腺癌行抗雄激素治疗
药品信息:

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 详细处方信息以本药内容附件PDF文件(201081723383714.pdf)的“原文Priscribing Information”为准
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部分中文ANDROCUR处方资料(仅供参考)

色普龙(ANDROCUR)

【通用名】醋酸环丙孕酮

【化学名】6-氯-1α,2α-亚甲基-4,6-孕甾二烯-17α-羟基-3,20-二酮-17-醋酸酯

【适应症】对不能手术的前列腺癌行抗雄激素治疗。

【用法用量】睾丸切除后去除肾上腺皮质雄激素的作用:每天1-2次口服色普龙(ANDROCUR)100毫克1片或50毫克2片(即100-200毫克)。
    未作睾丸切除者:每天2-3次口服色普龙(ANDROCUR)100毫克1片或2片(即200-300毫克)。药物应在饭后用水冲服。
    当发生病情缓解或改善后,医生所出据的治疗和剂量不能改变或停止。
    在用LHRH激动剂治疗时降低男性激素的升高:最初,每天2次口服色普龙(ANDROCUR)100毫克1片或50毫克2片(即200毫克),单独用药5-7天;然后,每天2次口服色普龙(ANDROCUR)100毫克1片或50毫克2片(即200毫克),与LHRH激动剂(剂量有生产商推荐)共同应用3-4周。
    在用LHRH激动剂治疗时去除肾上腺皮质雄激素的作用:每天1-2次口服色普龙(ANDROCUR)100毫克1片或50毫克2片(即100-200毫克),行持续抗性激素治疗。

【副作用】在用色普龙(ANDROCUR)治疗时,性欲和性能力降低。经过几周后色普龙(ANDROCUR)对男性生育能力逐渐产生影响。色普龙(ANDROCUR)偶然导致男性乳房发育(有时伴随乳房触痛)。在个别病例中,报道有大剂量色普龙(ANDROCUR)治疗时出现肝功能损坏,有些为重度损害。可能发生疲劳,精力低下;个别病理出现内心烦躁不安、情绪低落。体重可能有变化。

【禁忌症】肝脏疾病:杜一约综合症;罗托综合症;肝脏肿瘤(非转移性);消耗性疾病(不能手术的前列腺癌除外);长期重型抑郁症;血栓栓塞性疾病;有血栓栓塞性疾病或刀镰刀细胞性贫血或严重糖尿病管病变的患新、在进行色普龙(ANDROCUR)治疗前,对每种情况的危险;效益比必须仔细考虑。

【特别注意点】
1.应当指出,对从事高度注意力作业的患者(如驾驶员、机械操作人员),色普龙(ANDROCUR)可导致疲劳和精力下降而影响注意力。
2.在治疗期间,应当定期检查肝功能、肾上腺皮质功能和红细胞记数。
3.如果患者患有糖尿病,应当告知医生,因为这种病需要仔细地监控。
4.对抗糖尿病口服药或胰岛素的需要可能有改变。色普龙(ANDROCUR)可偶尔导致呼吸短促感。在极罕见的情况下,报道有短期应用色普龙引起血栓栓塞性疾病。但是,两者之间的关系值得质疑。正如象应用其他性类固醇激素一样,本药有引起良性和恶性肝脏病变的零星报道。在极罕见的情况下,肝脏肿瘤可引起致命性的腹腔内出血。因此,如果出现不同寻常的上腹部不适、短期内不能缓解,应当告知医生。

【生产厂家】先灵制药

Androcur (cyproterone acetate)
How does it work?

Androcur tablets contain the active ingredient cyproterone acetate, which is a type of medicine known as an anti-androgen. Cyproterone acetate is also available without a brand name, ie as the generic medicine.

Androgens are male hormones such as testosterone. Testosterone is produced by the testicles and is the main hormone essential for normal growth and development of the male sex organs and male sexual characteristics. During adult life, testosterone is essential for the production of sperm, the maintenance of sex drive, erectile potency, and the functioning of the prostate gland and other reproductive structures.

Cyproterone acts on an area of the brain called the hypothalamus and causes a reduction in the amount of testosterone produced by the body. It also prevents testosterone from binding to androgen receptors in other areas of the body. The result of this is a decrease in the amount of testosterone circulating in the body, which can help control sexual desire.

Androcur tablets are used to control sex drive in men with severe hypersexuality and or sexual deviation. Sexual deviation refers to men who prefer sexual practices that are biologically abnormal or considered morally wrong or illegal, for example paedophilia or bestiality.

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What is it used for?
Controlling sex drive in men with severely increased sex drive (hypersexuality) and/or deviant antisocial sexual behaviour such as bestiality or paedophilia.

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Warning!
Your doctor may ask you to sign a witnessed agreement to treatment before prescribing this medicine for you.

This medicine can make you feel tired or weak and so may reduce your ability to drive or operate machinery safely. Do not drive or operate machinery until you know how this medicine affects you and you are sure it won't affect your performance.

This medicine may sometimes cause liver problems. For this reason, your doctor will want to monitor your liver function before you start treatment and regularly during treatment. This will usually require a blood test. You should let your doctor know if you experience any symptoms that could indicate a problem with your liver during treatment, so that your liver function can be checked. Symptoms that could indicate liver problems include unexplained itching, nausea and vomiting, severe abdominal pain, loss of appetite or flu-like symptoms; yellowing of the skin or eyes (jaundice); or unusually dark urine.

On rare occasions this medicine may cause a type of anaemia. For this reason, your doctor will want to do a blood test to check your blood cells before you start treatment and regularly during treatment.

The functioning of your adrenal glands should also be monitored regularly while you are taking this medicine.

Your doctor may want to measure your sperm count before you start treatment with this medicine. This medicine will decrease your sperm count, but this change is reversible on stopping treatment. This medicine can also cause more of your sperms than usual to be abnormal in shape. It is possible that these abnormal sperms could produce birth defects. You should discuss this with your doctor before you start treatment with this medicine. The decrease in your sperm count will not happen at immediately and you should not rely on this medicine for contraception at any time.

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Use with caution in
Diabetes (particularly diabetes with complications, eg affecting the eyes, kidneys or blood circulation).

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Not to be used in
Women.
Children or adolescents under 18 years of age.
Men whose bones or testicles have not fully matured.
People who have had a meningioma (a tumour in the protective membranes around the brain and spinal cord).
Liver disease.
Malignant or cancerous disease (except prostate cancer).
Men who have ever had a blood clot in a vein (venous thromboembolism), eg in the leg (deep vein thrombosis) or in the lungs (pulmonary embolism).
Men who have ever had a blood clot in an artery, eg a stroke or mini-stroke (TIA) caused by a blood clot, or a heart attack.
Hereditary blood disorder called sickle cell anaemia.
Diabetes with complications affecting the blood circulation, eyes or kidneys.
Long-term severe depression.

This medicine should not be used if you are allergic to any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

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Label warnings
Take this medication with or after food.

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Side effects
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

Very common (affect more than 1 in 10 people)
Decreased sperm count (reversible on stopping treatment).
Reduced volume of ejaculation (reversible on stopping treatment).

Common (affect between 1 in 10 and 1 in 100 people)
Weight changes.
Depressive moods.
Restlessness.
Enlargement and tenderness of breasts (gynaecomastia).
Fatigue.

Uncommon (affect between 1 in 100 people and 1 in 1000 people)
Rash.

Rare (affect between 1 in 1000 and 1 in 10,000 people)
Shortness of breath.
Liver disorders.
Dryness of skin.
Abnormal blood clots in the blood vessels (thromboembolism).
Reduced growth of body hair and increased growth of scalp hair.
Abnormal production of breast milk (galactorrhoea).
Lightening of hair colour.
Severe allergic reaction.

Very rare (affect less than 1 in 10,000 people)
Osteoporosis.
Liver cancer.

The side effects listed above may not include all of the side effects reported by the medicine's manufacturer.

For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

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How can this medicine affect other medicines?
There are no significant interactions reported with this medicine.

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Other medicines containing the same active ingredient
Cyprostat 

Cyproterone acetate tablets are also available without a brand name, ie as the generic medicine.

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 详细处方信息以本药内容附件PDF文件(201081723383714.pdf)的“原文Priscribing Information”为准
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更新日期: 2011-12-28
附件:




201081723383714.pdf    

 
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