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 详细处方信息以本药内容附件PDF文件（201081521312129.pdf）的“原文Priscribing Information”为准
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部分中文NEOPROFEN处方资料（仅供参考）

中文名称： 布洛芬赖氨酸

中文别名： 2-甲基-对异丁基苯乙酸赖氨酸盐;布洛芬赖氨酸盐;IBUPROFEN LYSINE 99+%;赖氨洛芬

英文名称： Ibuprofen lysine

英文别名： L-Lysine mono[4-isobutyl-alpha-methylbenzeneacetate]

用　　途：用作解热镇痛药

Neoprofen
Generic Name: ibuprofen lysine (Intravenous route)
eye-bue-PROE-fen LYE-seen
Commonly used brand name(s):

In the U.S.
Neoprofen
Available Dosage Forms:
Solution
Therapeutic Class: Analgesic
Pharmacologic Class: Ibuprofen
Chemical Class: Ibuprofen

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Uses For Neoprofen
Ibuprofen lysine is used to treat patent ductus arteriosus (PDA) in premature infants (babies born too early) who weigh between 1.1 and 3.3 pounds. PDA is a heart problem where a blood vessel, the ductus arteriosus, fails to close normally after birth. This blood vessel is only used before birth, and is no longer needed after the baby is born. Ibuprofen lysine works by causing the PDA to constrict, and this closes the blood vessel .

This medicine is available only with your doctor's prescription .

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Before Using Neoprofen
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric
Appropriate studies performed to date have not demonstrated pediatrics-specific problems that would limit the usefulness of ibuprofen lysine in premature babies .

Pregnancy
Pregnancy Category Explanation

Breast Feeding
Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Ketorolac

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Ardeparin
Beta Glucan
Certoparin
Dalteparin
Danaparoid
Desirudin
Enoxaparin
Ginkgo
Methotrexate
Nadroparin
Parnaparin
Pemetrexed
Reviparin
Tacrolimus
Tinzaparin

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acetohexamide
Alacepril
Amikacin
Amiloride
Aspirin
Azosemide
Bemetizide
Benazepril
Bendroflumethiazide
Benzthiazide
Bumetanide
Buthiazide
Candesartan Cilexetil
Canrenoate
Captopril
Chlorothiazide
Chlorpropamide
Chlorthalidone
Cilazapril
Citalopram
Clopamide
Clopidogrel
Clovoxamine
Cyclopenthiazide
Cyclosporine
Cyclothiazide
Delapril
Desipramine
Desvenlafaxine
Duloxetine
Enalaprilat
Enalapril Maleate
Eprosartan
Escitalopram
Ethacrynic Acid
Femoxetine
Flesinoxan
Fluoxetine
Fluvoxamine
Fosinopril
Furosemide
Gliclazide
Glimepiride
Glipizide
Gliquidone
Glyburide
Hydrochlorothiazide
Hydroflumethiazide
Imidapril
Indapamide
Irbesartan
Lisinopril
Lithium
Losartan
Methyclothiazide
Metolazone
Milnacipran
Moexipril
Nefazodone
Olmesartan Medoxomil
Paroxetine
Pentopril
Perindopril
Phenytoin
Piretanide
Polythiazide
Quinapril
Quinethazone
Ramipril
Sertraline
Spirapril
Spironolactone
Tacrine
Tasosartan
Telmisartan
Temocapril
Tolazamide
Tolbutamide
Torsemide
Trandolapril
Triamterene
Trichlormethiazide
Valsartan
Venlafaxine
Xipamide
Zimeldine
Zofenopril

Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
Active bleeding (brain or intestine) or
Blood clotting problem (thrombocytopenia) or
Congenital heart disease or
Infection, untreated or
Kidney problem or
Necrotizing enterocolitis, known or suspected (an inflamed intestine)—This medicine should not be used in babies with these conditions .
Hyperbilirubinemia (high bilirubin in the blood)—May cause this condition to get worse .

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Precautions While Using Neoprofen
Ibuprofen lysine may change how the body reacts during an infection. Tell your baby's doctor if you notice any fever, chills, or other unusual behavior in your baby while this medicine is being used .

This medicine may affect the action of platelets, which are necessary for clotting the blood. This may increase the chance of bleeding for your baby. Call your baby's doctor right away if you notice any unusual bleeding or bruising, any dark-colored urine or stools, or other signs of bleeding in your baby .

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Neoprofen Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common
Abdominal cramps
abdominal pain or swelling
anxiety
black, tarry stools
bladder pain
blood in eyes
bloody or cloudy urine
blue lips, fingernails, or skin
bruising or purple areas on skin
bumps on skin
burning, itching, redness, or stinging of skin
chills
cold sweats
coma
cool, pale skin
cough
coughing up blood
darkening of skin
decreased alertness
decreased frequency or amount of urine
diarrhea
difficulty in breathing
fast heartbeat
fever
high blood pressure
increased blood pressure
increased hunger
increased thirst
indigestion
irregular, fast or slow, or shallow breathing
irregular heartbeats
irritability
joint pain or swelling
loss of appetite
muscle cramps in hands, arms, feet, legs, or face
muscle twitching
nausea or vomiting
nervousness
nosebleeds
passing of gas
rapid, shallow breathing
rash on skin
restlessness
seizures
shakiness
shortness of breath
sneezing
stomach pain, fullness, or discomfort
swelling of face, fingers, feet or lower legs
tremor
troubled breathing with exertion
unusual bleeding or bruising
unusual tiredness or weakness

Incidence not known
Bleeding, blistering, coldness, discoloration of skin, hives, infection, inflammation, itching, lumps, pain, rash, redness, scarring, soreness, swelling, tenderness, ulceration, or warmth at injection site
bleeding gums
blood in stools
chest pain or discomfort
clay-colored stools
dark urine
dilated neck veins
dry mouth
extreme fatigue
fast, pounding, or irregular heartbeat or pulse
flushed, dry skin
fruit-like breath odor
pinpoint red spots on skin
severe constipation
severe vomiting
stomach upset
sweating
swelling of abdominal or stomach area
tenderness in stomach area
ulcers, sores, or white spots in mouth
unexplained weight loss
unpleasant breath odor
vomiting of blood
weight gain
wheezing
yellow eyes or skin

Symptoms of overdose
Agitation
change in consciousness
drowsiness
lethargy
loss of consciousness
rapid weight gain
stupor
swelling of face, ankles, or hands
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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 详细处方信息以本药内容附件PDF文件（201081521312129.pdf）的“原文Priscribing Information”为准
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