Important information about Clolar
Do not use Clolar without telling your doctor if you are pregnant. It could harm the unborn baby. Use birth control to prevent pregnancy while you are receiving Clolar, whether you are a man or a woman. Clolar use by either parent may cause birth defects.
If you have liver or kidney disease, you may need a dose adjustment or special tests to safely receive Clolar.
To be sure Clolar is not causing harmful effects, your blood cells, kidney function, and liver function may need to be tested on a regular basis. Do not miss any follow-up visits to your doctor.
Clolar can lower the blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Avoid being near people who have colds, the flu, or other contagious illnesses. Contact your doctor at once if you develop signs of infection.
Clolar can be harmful to the liver or kidneys, and these effects are increased when you also use other medicines that can harm the liver or kidneys. During your 5-day treatment with Clolar, you may need to avoid using certain medications. Discuss all treatment options with your doctor if you regularly use any other medications.
Tell your caregivers at once if you have a serious side effect such as rapid breathing and heart rate, trouble breathing, painful swelling, numbness or tingling, feeling like you might pass out, lower back pain, blood in your urine, urinating less than usual, or jaundice (yellowing of the skin or eyes).

Before receiving Clolar
If you have liver or kidney disease, you may need a dose adjustment or special tests to safely receive Clolar.FDA pregnancy category D. Clolar can cause harm to an unborn baby or cause birth defects. Before you receive this medicine, tell your doctor if you are pregnant. Use birth control to prevent pregnancy while you are receiving Clolar, whether you are a man or a woman. Clolar use by either parent may cause birth defects. It is not known whether clofarabine passes into breast milk or if it could harm a nursing baby. Do not breast-feed while you are receiving Clolar.

How is Clolar given?
Clolar is given as an injection through a needle placed into a vein. You will receive this injection in a clinic or hospital setting. The medicine must be given slowly through an IV infusion, and can take at least 2 hours to complete.
Clolar is usually given daily for 5 days in a row during one or more treatment cycles. Your doctor will determine how many treatment cycles you will receive and how often.
You may receive other medications to help prevent certain side effects of Clolar.
Clolar can lower the blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill.
To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. Your cancer treatments may be delayed based on the results of these tests. Your kidney or liver function may also need to be tested. Do not miss any follow-up visits to your doctor.
Contact your doctor at once if you develop signs of infection such as fever, chills, sore throat, flu symptoms, pale skin, easy bruising or bleeding (nosebleeds, bleeding gums), purple or red pinpoint spots under your skin, loss of appetite, mouth sores, or unusual weakness.

What should I avoid while receiving Clolar?
Avoid being near people who have colds, the flu, or other contagious illnesses. Contact your doctor at once if you develop signs of infection.

Clolar side effects
Get emergency medical help if you have any of these signs of an allergic reaction to Clolar: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Tell your caregivers at once if you have a serious side effect such as:feeling like you might pass out;runny or stuffy nose, cough, rapid breathing and heart rate, trouble breathing, swelling and pain in any part of your body;lower back pain, blood in your urine, urinating less than usual or not at all;numbness or tingly feeling around your mouth;muscle weakness, tightness, or contraction, overactive reflexes;fast or slow heart rate, weak pulse, feeling short of breath, confusion, fainting;numbness or redness on the palms of your hands or the soles of your feet;jaundice (yellowing of the skin or eyes); or signs of infection such as fever, chills, sore throat, flu symptoms, pale skin, easy bruising or bleeding (nosebleeds, bleeding gums), purple or red pinpoint spots under your skin, loss of appetite, mouth sores, unusual weakness.

化学名称: 2-氯-9-(2-去氧-2-氟-β-D-阿拉伯呋喃)-9H-嘌呤-6-胺,2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine
英文名称: Clofarabine
药品名称：氯法拉滨
又名：Clofarabine，Clolar，卢伐拉滨，克罗拉滨
美国Bioenvision公司开发, Genzyme公司生产，04.12.28FDA快速审评通道批准本品上市。现本品未申请进口，原料制剂均为3.1类。Bioenvision公司于2006年5月宣布，欧盟委员会已经批准其clofarabine（Evoltra）上市。用于治疗急性淋巴细胞性白血病。本品适用范围为复发的或对至少2种疗法无应答且没有其它疗法可选用的儿科急性淋巴细胞性白血病患者。此外，本品还可用于初次诊断为白血病的21岁及以下患者。
适应症、用法用量：用于1～21岁顽固性或复发性急性淋巴细胞白血病（ALL）患者，患者此前至少接受过2种优先使用的疗法。本品先用5％葡萄糖注射液或0.9％NaCl注射液稀释。儿童推荐剂量为52mg/m2，每天输注2小时，连续5天。器官功能回复到基线后，治疗周期循环，大约每2～6周一次。
本品结合了氟达拉滨和克拉屈滨 的优点，既抑制DNA聚合酶，又抑制核糖核酸还原酶，是目前唯一可以特异性用于儿童白血病的药物；治疗白血病有效率高。两次常规化疗无应答的患者, 对该药的总反应率为31%；病人耐受性好，无不可预知的不良反应；具有潜在广谱抗肿瘤特性。

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