Information on LASILACTONE

Why is Lasilactone prescribed?
Lasilactone is used in the treatment of high blood pressure and other conditions that require the elimination of excess fluid (water) from the body. These conditions include congestive heart failure, cirrhosis of the liver, and kidney disease. When used to treat high blood pressure, Lasilactone is effective alone or in combination with other high blood pressure medications. Diuretics help your body produce and eliminate more urine, which helps lower blood pressure. Lasilactone is classified as a "loop diuretic" because of its point of action in the kidneys.
Lasilactone is also used with other drugs in people with fluid accumulation in the lungs.

Most important fact about Lasilactone
Lasilactone acts quickly, usually within 1 hour. However, since blood pressure declines gradually, it may be several weeks before you get the full benefit of Lasilactone; and you must continue taking it even if you are feeling well. Lasilactone does not cure high blood pressure; it merely keeps it under control.
How should you take Lasilactone?
Take Lasilactone exactly as prescribed by your doctor.

Lasilactone side effects
Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Lasilactone.
Side effects may include:
Anemia, blood disorders, blurred vision, constipation, cramping, diarrhea, dizziness, dizziness upon standing, fever, headache, hearing loss, high blood sugar, hives, itching, loss of appetite, low potassium (leading to symptoms like dry mouth, excessive thirst, weak or irregular heartbeat, muscle pain or cramps), muscle spasms, nausea, rash, reddish or purplish spots on the skin, restlessness, ringing in the ears, sensitivity to light, skin eruptions, skin inflammation and flaking, stomach or mouth irritation, tingling or pins and needles, vertigo, vision changes, vomiting, weakness, yellow eyes and skin.

Why should Lasilactone not be prescribed?
If you are sensitive to or have ever had an allergic reaction to Lasilactone or diuretics, or if you are unable to urinate, you should not take Lasilactone.
Special warnings about Lasilactone
Lasilactone can cause your body to lose too much potassium. Signs of an excessively low potassium level include muscle weakness and rapid or irregular heartbeat. To improve your potassium level, your doctor may prescribe a potassium supplement or recommend potassium-rich foods, such as bananas, raisins, and orange juice.
Make sure the doctor knows if you have kidney disease, liver disease, diabetes, gout, or the connective tissue disease, lupus erythematosus. Lasilactone should be used with caution.
If you are allergic to sulfa drugs, you may also be allergic to Lasilactone.
If you have high blood pressure, avoid over-the-counter medications that may increase blood pressure, including cold remedies and appetite suppressants.
Your skin may be more sensitive to the effects of sunlight.

Possible food and drug interactions when taking Lasilactone
If Lasilactone is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to consult with your doctor before taking Lasilactone with any of the following:
Aminoglycoside antibiotics such as Garamycin
Aspirin and other salicylates
Ethacrynic acid (Edecrin)
Indomethacin (Indocin)
Lithium (Lithonate)
Norepinephrine (Levophed) Other high blood pressure medications such as Hytrin and Cardura
Sucralfate (Carafate)

Overdosage
Any medication taken in excess can have serious consequences. An overdose of Lasilactone can cause symptoms of severe dehydration. If you suspect an overdose, seek medical attention immediately.
Symptoms of Lasilactone overdose may include:
Dry mouth, excessive thirst, low blood pressure, muscle pain or cramps, nausea and vomiting, weak or irregular heartbeat, weakness or drowsiness

If you miss a dose...
Take the forgotten dose as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at the same time.

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部分中文 LASILACTONE 处方信息（仅供参考）

药品成分：螺旋内酯固醇；呋塞米
螺旋内酯固醇简介
功能主治：临床上用于治疗与醛固酮升高有关的顽固性水肿，故对肝硬变和肾病综合征的病人较有效，而对充血性心力衰竭除非因缺钠而引起继发性醛固酮增多病人外，效果均较差。
不良反应和注意：1.服后可能引起头痛、嗜睡、精神紊乱、运动失调、皮疹及乳腺分泌过多等不良反应，并可引起低钠血症、高钾血症。2.可与氢氯噻嗪或汞剂利尿药合用，二者可取长补短，本品作用慢、弱和持久，而为后者作用较快、较强所弥补；而后者的排钾作用为前者所抵消，故合用后不仅疗效增加，而且不良反应减轻。
禁忌症：
(1)本药可通过胎盘，但对胎儿的影响尚不清楚。孕妇应在医师指导下用药，且用药时间应尽量短。
(2)老年人用药较易发生高钾血症和利尿过度。
(3)高钾血症患者禁用。
(4)下列情况慎用；①无尿；②肾功能不全；③肝功能不全，因本药引起电解质紊乱可诱发肝昏迷；④低钠血症；⑤酸中毒，一方面酸中毒可加重或促发本药所致的高钾血症；另一方面本药可加重酸中毒；⑥乳房增大或月经失调者。
肾功能衰竭及血钾偏高者忌用。
呋塞米简介
药理作用：为强有力的利尿剂，作用于亨氏袢升支。
适应症：临床上用于治疗心脏性水肿、肾性水肿、肝硬变腹水、功能障碍或血管障碍所引起的周围性水肿，并可促使上部尿道结石的排出。其利尿作用迅速、强大，多用于其他利尿药无效的严重病人。由于水、电解质丢失明显等原因，故不宜常规使用。
注意事项：1.可能出现轻微恶心、腹泻、药疹、瘙痒、视力模糊等不良反应，有时可发生起立性眩晕、乏力、疲倦、肌肉痉挛、口渴，少数病人有白细胞减少，个别病人出现血小板减少，多形性红斑、直立性低血压。长期应用可致胃及十二指肠溃疡。
2.由于能减少尿酸排出，故多次应用后能产生尿酸过多症，个别病人长期应用可产生急性痛风。
3.糖尿病病人应用后可使血糖增高；尽管其升血糖远较噻嗪类利尿药弱，但与降血糖药合并应用时，仍有使血糖增高的可能。
4.由于利尿作用迅速、强大，因而要注意掌握开始剂量，防止过度利尿，引起脱水和电解质失衡。
5.肝炎病人服用后，因电解质（特别是钾离子）过度丢失，易产生肝昏迷。
6.长期大量用药时，应注意检查血中电解质浓度。顽固性水肿病人特别容易出现低钾症状，在同时使用洋地黄或排钾的甾体激素时，更应注意补充钾盐。

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更新于2010年3月7日