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详细处方信息以本药内容附件PDF文件（2009122412113927.pdf）的“原文Priscribing Information”为准
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 部分中文 CYMBALTA 处方信息（仅供参考）

What is Cymbalta?
Cymbalta is an antidepressant in a group of drugs called selective serotonin and norepinephrine reuptake inhibitors (SSNRIs). Cymbalta affects chemicals in the brain that may become unbalanced and cause depression.Cymbalta is used to treat major depressive disorder and general anxiety disorder. It is also used to treat a chronic pain disorder called fibromyalgia, and to treat pain caused by nerve damage in people with diabetes (diabetic neuropathy).

Important information about Cymbalta
Do not take Cymbalta together with thioridazine (Mellaril), or a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate). You must wait at least 14 days after stopping an MAOI before you can take Cymbalta.

After you stop taking Cymbalta, you must wait at least 5 days before you start taking an MAOI.
You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.
Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself. Avoid drinking alcohol while taking Cymbalta. Alcohol may increase the risk of damage to your liver.
Cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures or anxiety can add to sleepiness caused by Cymbalta. Tell your doctor if you regularly use any of these other medicines.
Cymbalta can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

How should I take Cymbalta?
Take Cymbalta exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Your doctor may occasionally change your dose to make sure you get the best results from the medication.
Try to take the medicine at the same time each day. Follow the directions on your prescription label.
Do not crush, chew, break, or open a delayed-release capsule. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking or opening the pill would cause too much of the drug to be released at one time. It may take 4 weeks or longer for your symptoms to improve. For best results, keep using the medication as directed. Do not stop using Cymbalta without first talking to your doctor. You may have unpleasant side effects if you stop taking this medication suddenly. Store Cymbalta at room temperature away from moisture and heat.

Cymbalta side effects
Get emergency medical help if you have any of these signs of an allergic reaction to Cymbalta: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any new or worsening symptoms such as:
mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have any of these serious side effects while using Cymbalta:
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);painful or difficult urination;easy bruising or bleeding, nosebleeds;black, bloody, or tarry stools;very stiff (rigid) muscles, high fever, vomiting, diarrhea, sweating, fast or uneven heartbeats, tremors, overactive reflexes;headache, trouble concentrating, memory problems, confusion, hallucinations; or weakness,feeling unsteady, loss of coordination, fainting, seizure, shallow breathing or breathing that stops.
Less serious Cymbalta side effects may include:
dry mouth, blurred vision;drowsiness, dizziness, spinning sensation;mild nausea, constipation, gas;sleep problems (insomnia);joint or muscle pain;weight changes; or decreased sex drive, impotence, or difficulty having an orgasm.

【成　　份】 盐酸度洛西汀
【性　　状】 本品内容物为白色或类白色球状肠溶颗粒。 
【适 应 症】 用于治疗抑郁症。
【用法用量】 起始治疗：推荐本品的起始剂量为40mg/日（20mg一日二次）至60mg/日（一日一次或30mg一日二次），不考虑进食情况。现有的临床研究数据未证实剂量超过60mg/日将增加疗效。 维持／继续／长期治疗：一般认为抑郁症的急性发作需要数月或更长时间的药物治疗，但尚没有充足的试验资料来确定患者应该连续服用度洛西汀治疗达多长时间。对此类患者，应对其接受维持治疗的必要性以及相应所需的剂量作定期评估。 特殊人群：肾脏功能受损患者的用量一对于晚期肾脏疾病（需要透析的）患者， 或有严重肾脏功能损害（估计肌酐清除率〈30 mL/min的）患者，建议不用本品（见药理毒理）。 肝功能不全的患者的用量一建议有任何肝功能不全的患者避免服用本品（见药理毒理和注意事项） 老年患者的用量一对于老年患者，建议不必根据年龄调整剂量。与任何药物一样，治疗老年患者时应该慎重。在老年患者中个体化调整剂量时，增加剂量时应该额外小心。 对妊娠后三个月的女性患者的治疗一在妊娠后三个月内接触SSRIs或SNRls（五羟色胺和去甲肾上腺素再摄取抑制剂）的新生儿，产生的并发症会导致住院时间延长、需要呼吸支持和管道喂食（见注意事项）。当孕期女性用度洛西汀治疗时，在妊娠后三个月，医生应对治疗的潜在风险和获益进行认真的评价。医生应考虑在妊娠晚期逐渐减度洛西汀的用量。 度洛西汀停药 已有报道本品及其他SSRI和SNRIs药物的停药反应（见注意事项）。停药时应对这些症状进行监测。建议尽可能的逐渐减药，而不是骤停药物。由于减少药物剂量或停药而引起了无法耐受的症状时，可以考虑恢夏使用以往的的处方剂量。随后再以更慢的的速度减药。 与单胺氧化酶抑制剂(MOA I)间的换药 MOAT停药后至少14天才可开始本品的治疗。本品停药后至少5天才可以开始MOAT的治疗。
 【不良反应】 最常见的不良反应（发生率≧5%，且至少是安慰剂组发生率的两倍）包括恶心、口干、便秘、食欲下降、疲乏、嗜睡、出汗增多（详情请咨询专科医生） 尿急－度洛西汀属于已知的影响尿道阻力的药物。如果应用度洛西汀治疗的过程中出现尿急，应当考虑药物导致的可能性。
【禁 忌】 度洛西汀肠溶胶囊禁用于已知对度洛西汀肠溶胶囊或产品中任何非活性成分过敏的患者。 ◇禁止与单胺氧化酶抑制剂（MAOIs）联用。 ◇未经治疗的窄角型青光眼 ◇临床试验显示，度洛西汀有增加瞳孔散大的风险， 未经治疗的窄角型青光眼患者应避免使用度洛西汀。
【孕妇及哺乳期妇女用药】 妊娠分类C一在动物生殖研究中，发现度洛西汀对胚胎/胎儿和出生后的发育有不良影响。
【儿童用药】对于儿童患者的疗效和安全性尚不清楚。如考虑在儿童青少年中使用度洛西汀，必须权衡潜在的风险和临床需要。
【老年用药】 在度洛西汀治疗抑郁症（MDD）临床研究的2418例患者中，5.9%(143)为65岁以上年龄的患者。这些患者和年轻患者间未观察到安全性和疗效方面的显著差异，其他临床方面的报告也没有发现老年人群和年轻人之间的明显差异，但不能排除某些老年息者的敏感性增高。

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详细处方信息以本药内容附件PDF文件（2009122412113927.pdf）的“原文Priscribing Information”为准
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