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  药店国别: 美国药房
产地国家: 美国
所属类别: 心血管系统药物->降血脂药物
处方药:处方药
包装规格: 40毫克/片 90片/瓶
计价单位:
  点击放大  
该药品相关信息网址1:
http://app1.sfda.gov.cn/webportal/portal.po?UID=DWV1_WOUID_URL_11635827&&POpType=DBSearch&subSearch=dbDetail&dbDetail=7349&selDbName=PLDB_TBL_TABLE8&tblCol=OID&mainUid=dj
该药品相关信息网址2:
http://www.drugs.com/lipitor.html
原产地英文商品名:
ATORVASTATIN(LIPITOR GENERIC) 40mg/tab 90Tabs/bottle
原产地英文药品名:
ATORVASTATIN CALCIUM
原产地英文化合物名称:
[R-(R*, R*)]-2-(4-fluorophenyl)-β, δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1Hpyrrole-1-heptanoic acid, calcium salt (2:1) trihydrate
中文参考商品译名:
阿托伐他汀(立普妥仿制药) 40毫克/片 90片/瓶
中文参考药品译名:
阿托伐他汀钙
中文参考化合物名称:
[R-(R′, R′)]-2-(4-氟苯基)--二羟基-5-(1-甲基乙基)- 3-苯基-4-[(苯胺)羰基]-1-氢-吡咯-1-庚酸钙三水合物
原产地国家批准上市年份:
1996/12/17
英文适应病症1:
Hypercholesterolaemia
英文适应病症2:
Dyslipidaemia
临床试验期:
完成
中文适应病症参考翻译1:
高胆固醇血症
中文适应病症参考翻译2:
血脂障碍
药品信息:

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 详细处方信息以本药内容附件PDF文件(2009121908304040.pdf)的“原文Priscribing Information”为准
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部分中文阿托伐他汀钙处方资料(仅供参考)

What is Lipitor?
Lipitor is a cholesterol-lowering medication that blocks the production of cholesterol (a type
of fat) in the body.Lipitor reduces low-density lipoprotein (LDL) cholesterol and total cholesterol in the blood. Lowering your cholesterol can help prevent heart disease and hardening of the arteries, conditions that can lead to heart attack, stroke, and vascular disease.  

 Lipitor is used to treat high cholesterol. Lipitor is also used to lower the risk of stroke, heart attack, or other heart complicationsin people with coronary heart disease or type 2 diabetes.Lipitor may also be used for other purposes not listed in this medication guide.

How should I take Lipitor?
Take Lipitor exactly as it was prescribed for you. Do not take the medication in larger amounts,
or take it for longer than recommended by your doctor. Follow the directions on your prescription label.Take Lipitor with a full glass of water. This medication can be taken with or without food.
Lipitor is usually taken once a day. Try to take your dose at the same time each day. Follow
your doctor's instructions.
To be sure this medication is helping your condition, your blood will need to be tested on a
regular basis. Your liver function may also need to be tested. Do not miss any scheduled appointments.
In rare cases, Lipitor can cause a condition that results in the breakdown of skeletal muscle
tissue. This condition can lead to kidney failure. Call your doctor at once if you have unexplained muscle pain or tenderness, muscle weakness, fever or flu symptoms, and dark colored urine.
Lipitor is only part of a complete program of treatment that also includes diet, exercise, and
weight control. Follow your diet, medication, and exercise routines very closely.

What should I avoid while taking Lipitor?
Avoid eating foods that are high in fat or cholesterol. Lipitor will not be as effective in
lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.Avoid drinking alcohol while taking Lipitor. Alcohol can raise triglyceride levels, and may also damage your liver while you are taking Lipitor.Grapefruit and grapefruit juice may interact with Lipitor and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

Lipitor side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives;
difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using Lipitor and call your doctor at once if you have any of these serious side effects:
muscle pain, tenderness, or weakness with fever or flu symptoms; ornausea, stomach pain, low
fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Less serious Lipitor side effects may include:mild nausea or stomach pain, stomach upset,
heartburn;constipation, bloating, gas;stuffy nose;itching, skin rash; or headache.

【通用名】:阿托伐他汀钙片
【商品名称】:立普妥、阿乐
【英文名】:Atorvastatin Calcium Tablets
【主要成分】:本品化学名称为:[R-(R′, R′)]-2-(4-氟苯基)--二羟基-5-(1-甲基乙基)- 3-苯基-4-[(苯胺)羰基]-1-氢-吡咯-1-庚酸钙三水合物。                           
【分子式】:( C33H34 FN2O5)2Ca·3H2O
【分子量】:1209.42
【药理作用】本品为他汀类血脂调节药,属HMG-CoA还原酶抑制剂。本身无活性,口服吸收后的水解产物在体内竞争性地抑制胆固醇合成过程中的限速酶羟甲戊二酰辅酶A还原酶,使胆固醇的合成减少,也使低密度脂蛋白受体合成增加,主要作用部位在肝脏,结果使血胆固醇和低密度脂蛋白胆固醇水平降低,中度降低血清甘油三酯水平和增高血高密度脂蛋白水平。由此对动脉粥样硬化和冠心病的防治产生作用。
【药代动力学】本品口服吸收良好,因经肝内广泛首关代谢,绝对生物利用度较低,大约为12%,本品在肝脏经细胞色素P450 3A4代谢为多种活性代谢物。阿托伐他汀的平均血浆半衰期大约为14小时,但由于其活性代谢物的影响,实际对HMG-CoA还原酶抑制作用的半衰期为20~30小时。本品蛋白结合率为98%,大部分以代谢物的形式经胆汁排出。
【适应证】用于治疗高胆固醇血症和混合型高脂血症;冠心病和脑中风的防治。
【用法用量】成人常用量 口服:10~20mg,每日1次,晚餐时服用。剂量可按需要调整,但最大剂量不超过每日80mg。
【不良反应】(1)本品最常见的不良反应为胃肠道不适,其他还有头痛、皮疹、头晕、视觉模糊和味觉障碍。(2)偶可引起血氨基转移酶可逆性升高。因此需监测肝功能。(3)少见的不良反应有阳痿、失眠。(4)罕见的不良反应有肌炎、肌痛、横纹肌溶解,表现为肌肉疼痛、乏力、发烧,并伴有血肌酸磷酸激酶升高、肌红蛋白尿等,横纹肌溶解可导致肾功能衰竭,但较罕见。本品与免疫抑制剂、叶酸衍生物、烟酸、吉非罗齐、红霉素等合用可增加肌病发生的危险。(5)有报道发生过肝炎、胰腺炎及过敏反应如血管神经性水肿。
【禁忌】(1)对阿托伐他汀过敏的患者禁用。对其他HMG-CoA还原酶抑制剂过敏者慎用。(2)有活动性肝病或不明原因血氨基转移酶持续升高的患者禁用。
【注意事项】(1)用药期间应定期检查血胆固醇和血肌酸磷酸激酶。应用本品时血氨基转移酶可能增高,有肝病史者服用本品还应定期监测肝功能试验。(2)在本品治疗过程中如发生血氨基转移酶增高达正常高限的3倍,或血肌酸磷酸激酶显著增高或有肌炎、胰腺炎表现时,应停用本品。(3)应用本品时如有低血压、严重急性感染、创伤、代谢紊乱等情况,须注意可能出现的继发于肌溶解后的肾功能衰竭。(4)肾功能不全时应减少本品剂量。(5)本品宜与饮食共进,以利吸收。(6)饮食疗法始终是治疗高血脂的首要方法,加强锻炼和减轻体重等方式,都将优于任何形式的药物治疗。
【相互作用】(1)本品与口服抗凝药合用可使凝血酶原时间延长,使出血的危险性增加。(2)本品与免疫抑制剂如环孢素、红霉素、吉非罗齐、烟酸等合用可增加肌溶解和急性肾功能衰竭发生的危险。(3)考来替泊、考来烯胺可使本品的生物利用度降低,故应在服用前者4小时后服用本品。
【孕妇及哺乳期妇女用药】由于在动物实验中本品可导致胎儿发育不良及在母乳中是否有排泌尚不清楚,故在孕妇及乳母不推荐使用。
【儿童用药】在儿童中的使用有限,长期安全性未确立。
【老人用药】老年患者需根据肝肾功能调整剂量。
【剂型】片剂
【贮藏】密封,25℃以下干燥处保存。   

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 详细处方信息以本药内容附件PDF文件(2009121908304040.pdf)的“原文Priscribing Information”为准
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更新日期: 2012-2-17
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