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  药店国别: 新西兰药房
产地国家: 新西兰
所属类别: 心血管系统药物->抗高血压药物
处方药:处方药
包装规格: (5/12.5)毫克/片 28片/盒
计价单位:
  点击放大  
生产厂家中文参考译名:
罗氏
生产厂家英文名:
ROCHE
该药品相关信息网址1:
http://www.drugs.com/mmx/inhibace.html
该药品相关信息网址2:
http://www.medbroadcast.com/drug_info_details.asp?brand_name_id=77
该药品相关信息网址3:
http://chealth.canoe.ca/drug_info_details.asp?brand_name_id=1957&rot=4
原产地英文商品名:
Inhibace Plus (5/12.5)mg/tab 28tabs/box
原产地英文药品名:
Cilazapril/hydrochlorothiazide
中文参考商品译名:
抑平舒Plus (5/12.5)毫克/片 28片/盒
中文参考药品译名:
西拉普利/氢氯噻嗪
原产地国家批准上市年份:
0000/00/00
英文适应病症1:
Hypertension
英文适应病症2:
Chronic heart failure
临床试验期:
完成
中文适应病症参考翻译1:
高血压
中文适应病症参考翻译2:
性心力衰竭
药品信息:

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 详细处方信息以本药内容附件PDF文件(201211721352233.pdf)的“原文Priscribing Information”为准
---------------------------------------------------------------
部分中文西拉普利处方资料(仅供参考)

【英文名】:GILAZAPRIL TABLETS

【拼音名】:XILAPULI PIAN

【药品类别】:抗高血压药

【性状】:薄膜衣片,为粉红色刻痕片,除去薄膜衣后显白色。 

【药理毒理】:本品为血管紧张素转换酶抑制剂,口服吸收转化为药理活性的西拉普利拉,它使血管紧张素Ⅰ不能转换为血管紧张素Ⅱ,并使血浆肾素活性增高、醛固酮分泌减少,从而使血管舒张、血管阻力降低而产生降压作用。
药代动力学 西拉普利能有效被吸收并迅速地被转化为具有药理活性的西拉普利拉。进食后服用会轻微减慢和降低其吸收率,但并不影响疗效。根据尿液回收资料分析,口服抑平舒后的西拉普利拉的生物利用度约为60%。用药后两小时内达到血药峰浓度,浓度与剂量有直接关系。每日一次服用后,西拉普利拉的有效半衰期为9小时,并以原形从肾脏排除。肾功能不全病人,当肌酐清除率降低时,药物清除率也随之降低,故这类病人的西拉普利拉的血药浓度比肾功能正常的病人要高些。肾功能完全丧失者,肾脏失去清除能力,但可通过血液透析使西拉普利和西拉普利拉的血药浓度减低至一定范围之内。肾功能正常的老年病人,其西拉普利拉血药浓度要比年轻病人高40%,药物清除率要较之低20%。中度到重度肝硬化病人的药代动力学改变和老年病人相似。慢性心力衰竭病人的西拉普利拉清除率与肌酐清除率密切相关。所以剂量必需按照病人的肾功能进行调整(见特殊用药指导)。

【适应症】 用于治疗各种程度原发性高血压和肾性高血压,也可与洋地黄和(或)利尿剂合用作为治疗慢性心力衰竭的辅助药物。

【用法用量】:口服:每日一次,餐前或餐后服药均可。应在每天的同一时间内服药。

【特殊剂量指导】:1.原发性高血压:通常剂量范围是2.5~5.0mg,每日一次。推荐的起始剂量为1mg片剂,每日一次。起始剂量很少能达到所需的疗效,应根据每个病人的血压情况分别调整剂量。如每日一次5mg仍不能控制血压时,则可加用非潴钾利尿药以增强其降压效果。
2.肾性高血压:与原发性高血压相比,血管紧张素转换酶抑制剂能更显著地减低肾性高血压。所以治疗肾性高血压时,起始剂量应为0.5mg或0.25mg,每日一次。维持剂量应按个体调整。
3.服用利尿剂的高血压病人:在用治疗前2~3天,应停用利尿剂以减少可能发生的症状性低血压。但如需要,以后可再恢复使用。这类病人的推荐起始剂量为0.5mg,每日一次。
4.慢性心力衰竭:可与洋地黄和(或)利尿剂联合使用,作为治疗慢性心力衰竭病人的辅助药物,起始剂量应以0.5mg,每日一次,并在严格的医生指导下进行。可根据耐受情况及临床状况将剂量增加至1mg,每日一次的最大维持剂量。此外,若需要把维持剂量调整至1~2.5mg之间,应根据病人的反应、临床状况及耐受性而进行调整。通常最大剂量为5mg,每日一次。临床试验结果证明,慢性心力衰竭病人的西拉普利拉清除率与肌酐清除率相互关联,因此慢性心力衰竭和肾功能不全病人应按肾功能不全一节所推荐的剂量用药。根据肾功能不全病人的肌酐清除率,而减少剂量,下面是推荐的用药方案:肌酐清除率 起始剂量 最大剂量 >40ml/min 1mg每日一次 5mg每日一次 10~4ml/min 0.5mg每日一次 2.5mg每日一次>10ml/min 根据血压情况 0.25~0.5mg 每周1~2次需要血液透析的病人,应在不进行透析的日子服用,剂量应根据血压情况调整。如同其它血管紧张素转换酶抑制剂一样,使用高流量聚丙烯腈膜透析时会产生过敏反应,要避免这种情况,就应改用其它降压药,或是改换透析膜种类。
5.肝硬化:在极少情况下肝硬化病人需服用。由于可能会导致严重的低血压,故必须以0.5mg或0.25mg每日一次的起始剂量谨慎用药。
6.老年人:以每日0.5mg片剂作为起始剂量进行治疗,并根据不同病人的耐受性、疗效及临床状况以1~2.5mg的维持剂量用药。
7.儿童:由于尚未定出对儿童的药物效能及安全范围,故尚无法推荐儿童服用方案。

【不良反应】:最常报道的不良反应是头痛与头晕。其它发生率少于2%的不良反应包括乏力,低血压、消化不良、恶心、皮疹和干咳。大多数不良反应是短暂性的,轻度或中度,无需中止用药。服用慢性心力衰竭病人最常报道的不良反应是头晕及咳嗽。特异性反应:与其它血管紧张素转换酶抑制剂一样,罕有血管神经性水肿的报道。但由于此症可能伴有喉头水肿,故一旦波及面部、口唇、舌、声带和(或) 喉头时,必须立刻停用并进行适当治疗。某些病人中有血红蛋白、红细胞压积和(或)白细胞计数降低的报告,但尚无病例证明与本品有明确关系。
禁忌症 禁用于对该药或其它血管紧张素转换酶抑制剂过敏或患有腹水的病人。由于动物试验中发现血管紧张素转换酶抑制剂具有胚胎毒性,故禁用于妊娠期妇女。已发现其它类型的血管紧张素转换酶抑制剂与妊娠期羊水过少以及新生儿低血压和无尿有关。

【注意事项】:1.禁用于主动脉瓣狭窄或心脏流出道阻塞病人。 2.症状性低血压: (1)用血管紧张素转换酶抑制剂治疗偶见症状性低血压的报告。特别是因呕吐、腹泻,先已服用利尿剂、低钠饮食或血透后腹水低钠或低血容量的病人。 (2)急性低血压病人必须平卧休息,必要时静脉滴注生理盐水或扩容剂。血容量恢复后,也可以继续治疗,但如低血压持续存在,则应减少剂量或中止用药。 (3)慢性心力衰竭病人用可能会导致血压显著降低,但在以0.5mg的起始剂量的临床试验中,用药后未发现症状性低血压。 3.肾功能不全病人使用时,可根据病人的肌酐清除率而减少剂量。与其它血管紧张素转换酶抑制剂一样,用于单侧或双侧肾动脉狭窄病人时,可能会使尿素氮和血肌酐增加,这些改变通常能随着中止用药和(或)给予利尿剂治疗而恢复。 4.外科麻醉:血管紧张素转换酶抑制剂与具有降压作用的外科麻醉剂合用时,能导致动脉性低血压,发生这种情况时,则应以静脉输液法扩大血容量。无效时,应静脉滴注血管紧张素Ⅱ。 5.过敏样反应:虽然过敏样反应机理尚未确立,但已有临床显示,病人在服用血管紧张素转换酶抑制剂期间(包括西拉普利),若使用高流量多丙烯腈膜继续血透、血过滤或LDL分离性输血,可导致过敏性反应或过敏样反应,包括危及生命的休克。故正在接受血管紧张素转换酶抑制剂的病人一定要避免以上各种治疗。 6.此外,若病人在服用血管紧张素转换酶抑制剂期间,同时接受用黄蜂或蜜蜂毒液作脱敏治疗,可能发生过敏性反应。因此,在接受脱敏治疗前一定要停止服用西拉普利,在这种情况下,不可用β-阻断剂来代替西拉普利。

【孕妇及哺乳期妇女用药】:尚不明确本品是否能进入人类乳汁中,但由于动物资料显示少量小鼠乳汁含有西拉普利拉,故哺乳期妇女不应使用本品。

【老年患者用药】:对使用大剂量利尿剂的老年慢性心力衰竭病人开始使用应严格按推荐的 0.5mg起始剂量用药。

【药物相互作用】:1.本品已与地高辛、硝酸盐类、速尿、噻唑类,口服抗糖尿病药物以及H2受体阻断剂等合用过,未见有地高辛浓度增高及其它具有临床意义的药物相互作用。但当本品与其它降压药物合用时可能会引起相加作用。 2.本品与潴钾利尿剂合用,可引起血钾增高,特别是在肾功能不全者。 3.和其它血管紧张素转换酶抑制剂一样,与非甾体抗炎药物合用时,可能会降低本品的降压作用。在使用非甾体抗炎药物之前使用本品的病人则不发生以上情况。

Brand Name
Inhibace

Common Name
cilazapril

DIN (Drug Identification Number)
01911473  INHIBACE 2.5MG TABLET
01911481  INHIBACE 5MG TABLET

How does this medication work? What will it do for me?
Cilazapril belongs to the family of medications known as ACE inhibitors. It is used to treat high blood pressure and congestive heart failure. Cilazapril controls blood pressure and reduces symptoms of congestive heart failure by relaxing blood vessels and by making the heart pump more efficiently.

For treatment of high blood pressure, cilazapril may be used alone or in combination with diuretics (water pills) known as thiazide diuretics (e.g., hydrochlorothiazide) when one medication has not been found to control blood pressure satisfactorily.

For treatment of congestive heart failure, cilazapril is used in addition to digoxin or thiazide diuretics or both.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

How should I use this medication?
The usual recommended doses range from 2.5 mg to 10 mg once daily, depending on the condition being treated as well as the person's kidney and liver function. The initial starting dose may be as low as 0.5 mg once daily. Cilazapril should be taken at the same time each day, with or without food.

The dose range for treatment of high blood pressure is 2.5 mg to 10 mg once daily.

The dose range for congestive heart failure is 2.5 mg to 5 mg once daily taken.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important that this medication be taken exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

This medication is available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms listed here. The forms available for the specific brand you have searched are listed under "What form(s) does this medication come in?"

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

What form(s) does this medication come in?
2.5 mg
Each pinkish-brown, oval-shaped, single-scored, biconvex, film-coated tablet, imprinted "CIL 2.5", contains cilazapril 2.5 mg as cilazapril monohydrate. Nonmedicinal ingredients: cornstarch, hydroxypropyl methylcellulose, iron oxide, lactose, sodium stearyl fumarate, talc, and titanium dioxide.

5 mg
Each reddish-brown, oval-shaped, single-scored, biconvex tablet, imprinted "CIL 5", contains cilazapril 5 mg as cilazapril monohydrate. Nonmedicinal ingredients: cornstarch, hydroxypropyl methylcellulose, iron oxide, lactose, sodium stearyl fumarate, talc, and titanium dioxide.

Who should NOT take this medication?
Cilazapril should not be taken by anyone who:
is allergic to cilazapril or to any ingredients of this medication
is pregnant
has a history of angioedema (a serious allergic reaction which causes the area around the throat and tongue to swell) after taking any ACE inhibitors
has ascites (swollen abdomen due to liver problems)

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 详细处方信息以本药内容附件PDF文件(201211721352233.pdf)的“原文Priscribing Information”为准
---------------------------------------------------------------

更新日期: 2012-1-18
附件:
201211721352233.PDF    

 
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