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当前本网站药物产品种数共 8524 处方药 8148 非处方药 269 保健品/医疗用具 107

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  药店国别: 美国药房
产地国家: 美国
所属类别: 抗癌药物->治疗白血病药物
处方药:处方药
包装规格: 2毫克/片 50片/盒
计价单位:
  点击放大  
生产厂家中文参考译名:
PBS
生产厂家英文名:
PBS
该药品相关信息网址1:
http://www.drugs.com/pro/leukeran.html
该药品相关信息网址2:
http://www.rxlist.com/leukeran-drug.htm
该药品相关信息网址3:
http://www.chemocare.com/bio/leukeran.asp
原产地英文商品名:
LEUKERAN 2MG/TAB 50TABS/BOTTLE
原产地英文药品名:
CHLORAMBUCIL
中文参考商品译名:
留可然 2毫克/片 50片/盒
中文参考药品译名:
苯丁酸氮芥
曾用名:
瘤可宁
原产地国家批准上市年份:
1957/03/18
英文适应病症1:
Hodgkin's disease
英文适应病症2:
Non-Hodgkin's disease lymphoma
英文适应病症3:
Chronic lymphocytic leukemia
英文适应病症4:
Ovarian adenocarcinoma
英文适应病症5:
Breast cancer
临床试验期:
完成
中文适应病症参考翻译1:
霍奇金病
中文适应病症参考翻译2:
非霍奇金病淋巴瘤
中文适应病症参考翻译3:
慢性淋巴细胞性白血病
中文适应病症参考翻译4:
卵巢腺癌
中文适应病症参考翻译5:
乳腺癌
药品信息:

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 详细处方信息以本药内容附件PDF文件(201231922482318.pdf)的“原文Priscribing Information”为准
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部分中文留可然处方资料(仅供参考)

英文药名: Leukeran (Chlorambucil)

中文药名: 留可然(苯丁酸氮芥)

药品名称
通用名称:苯丁酸氮芥片
商品名称:留可然
英文名称:Chlorambucil Tablets
汉语拼音:Bendingsuandanjie Pian

药理作用
本品属氮芥类衍生物,具有双功能烷化剂作用,可形成不稳定的乙撑亚胺而发挥其细胞毒作用,干扰 DNA 和 RNA 的功能。在常规剂量下,其毒性较其他任何氮芥类药物小。对增殖状态的细胞敏感,特别对 G1 期与 M 期的作用最强,属细胞周期非特异性药物。对淋巴细胞有一定的选择性控制作用。

药代动力学
口服吸收完全,生物利用度大于 70% ,在 1 小时内,肝脏可达最高的组织浓度。其代谢产物苯乙酸氮芥于用药后 2 ~ 4 小时在血浆中达峰值,其血浆浓度与原形相当,半衰期 1 ~ 2 小时,药时曲线下面积大,具有双功能烷化剂作用。 24 小时内 60% 的药物随尿排出,其中 90% 为苯丁酸氮芥和苯乙酸氮芥的水解物。部分的药物分子有亲脂肪特性而储存于脂肪中,从而延长本品的临床作用时间。

适应症
霍奇金病,数种非霍奇金病淋巴瘤,慢性淋巴细胞性白血病,瓦尔登斯特伦巨球蛋白血症,晚期卵巢腺癌。本品对于部分乳腺癌病人也有明显的疗效。

用法用量
每日 0.1 ~ 0.2mg/kg(6 ~ 10mg) 或( 4 ~ 8mg/m2 ),每日 1 次或分 3 ~ 4 次口服,连用 3 ~ 6 周, 1 疗程总量可达 300 ~ 500mg 。

不良反应
骨髓抑制:属中等程度,主要表现为白细胞减少,对血小板影响较轻,但大剂量连续用药时可出现全血象下降。
胃肠道反应:较轻,多为食欲减退、恶心,偶见呕吐。
生殖系统反应:长期应用本品可致精子缺乏或持久不育,月经紊乱或停经。
其他少见的不良反应尚包括中枢神经系统毒性、皮疹、脱发、肝损害及发热等,长期或高剂量应用可导致间质性肺炎。

禁忌
凡有严重骨髓抑制、感染者禁用,有痛风病史、泌尿道结石者慎用。对本品过敏者禁用。

注意事项
本品给药时间较长,疗效及毒性多在治疗3周以后出现,故应密切观察血相变化,并注意蓄积毒性。

GENERIC NAME: CHLORAMBUCIL - ORAL (klor-AM-byou-sill)

BRAND NAME(S): Leukeran

WARNING: Chlorambucil treatment can be associated with serious side effects. Although chlorambucil is used to treat cancer, it may increase your risk of developing another form of cancer. Consult your doctor for more details. This medication can also decrease your bone marrow function, lowering your body's ability to fight an infection. Tell your doctor immediately if you develop unusual growths or lumps, swollen glands, signs of infection (e.g., fever, chills, persistent sore throat or cough), unusual or easy bruising/bleeding, or unusual fatigue.

Chlorambucil may damage chromosomes (genes) and cause birth defects. It may also possibly leave men and women unable to have children in the future (sterility).

Discuss the risks and benefits of treatment with your doctor.

USES: This medication is used to treat certain types of cancer (e.g., leukemia, lymphoma). Chlorambucil is a chemotherapy drug that works by slowing or stopping cell growth.OTHER This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.This drug may also be used for certain blood diseases, certain types of kidney disease in children that have not responded to other treatment, and other conditions as determined by your doctor.

HOW TO USE: Take this medication by mouth exactly as directed by your doctor. Unless your doctor directs you otherwise, drink plenty of fluids while taking this medication. This will help prevent side effects.The dosage is based on your medical condition, weight, and response to therapy. Do not increase your dose or take this medication more often without your doctor's approval. Your condition will not improve any faster and the risk of serious side effects may be increased.Since this drug can be absorbed through the skin, women who are pregnant or who may become pregnant should not handle or break the tablets of this medication.

SIDE EFFECTS: See also Warnings section.Nausea, vomiting, stomach upset, diarrhea, and loss of appetite may occur. Changes in diet such as eating several small meals or limiting physical activity may help lessen the chance of nausea. In some cases, drug therapy may be necessary to prevent or relieve nausea and vomiting. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: mouth sores, shaking/tremors, muscle problems (e.g., twitching, stiffness, weakness), unsteadiness, joint pain, lower back pain/side pain, frequent/painful urination, numbness/tingling of the hands or feet, swelling of the legs/feet, mental/mood changes (e.g., confusion, hallucinations), stopping of menstrual periods.Tell your doctor immediately if any of these rare but very serious side effects occur: seizures, trouble breathing, severe stomach/abdominal pain, yellowing of the skin/eyes, dark urine, inability to move arms/legs.A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking chlorambucil, tell your doctor or pharmacist if you are allergic to it; or to other chemotherapy drugs (e.g., busulfan, cyclophosphamide); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: seizures, head injury, gout, kidney stones, blood disorders (e.g., anemia, neutropenia, thrombocytopenia).Do not have immunizations/vaccinations without the consent of your doctor and avoid contact with people who have recently received oral polio vaccine.Use caution with sharp objects like razors or nail cutters and avoid activities such as contact sports to lower the chance of getting cut, bruised or injured.Wash your hands well to prevent the spread of infections.Caution is advised when using this drug in children because they may be more sensitive to its effects, especially possible infertility later in life. Children treated for a certain kidney disease (nephrotic syndrome) may be more at risk for seizures.This drug is not recommended for use during pregnancy. It may cause harm to an unborn baby. Women of childbearing age and men should use reliable form(s) of birth control during treatment with this drug. Consult your doctor for more details.It is not known whether this drug passes into breast milk. Because of the potential risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.This drug should not be used with the following medication because very serious interactions may occur: nalidixic acid.If you are currently using the medication listed above, tell your doctor or pharmacist before starting chlorambucil.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use.Also report the use of drugs which might increase seizure risk (decrease seizure threshold) when combined with chlorambucil such as isoniazid (INH), phenothiazines (e.g., thioridazine), theophylline, or tricyclic antidepressants (e.g., amitriptyline), among others. Consult your doctor or pharmacist for details.This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly. Symptoms of overdose may include seizures.

NOTES: Do not share this medication with others.Laboratory and/or medical tests (e.g., complete blood counts, uric acid levels) should be performed to monitor your progress or check for side effects. Consult your doctor for more details. It is important that you keep all medical appointments.

MISSED DOSE: It is important you receive each scheduled dose of this medication as directed. If you miss a dose, contact your doctor to establish a new dosing schedule. Do not double the dose to catch up.

STORAGE: Store in a refrigerator between 36-46 degrees F (2-8 degrees C) away from light and moisture. Do not freeze. Keep all medicines away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.MEDICAL ALERT: Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).

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 详细处方信息以本药内容附件PDF文件(201231922482318.pdf)的“原文Priscribing Information”为准
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更新日期: 2012-3-20
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