部分中文立妥威信息资料（仅供参考）
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 详细处方信息以本药内容附件PDF文件（200961503465235.pdf）的“原文Priscribing Information”为准
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【中文名】：齐多夫定
【英文名】：Zidovudine
【化学名】：3'-叠氮-3'-脱氧胸腺嘧啶核苷
CAS 30516-87-1
【国外商品名】：Retrovir 立妥威
【适应症】：(1)治疗人类免疫缺陷病毒(HIV)感染；(2)预防HIV母婴传染。
【用法用量】：用法：口服；用量：(1)治疗HIV感染，成人每天600mg(6粒)，6周至12岁的儿童按体表面积一次160mg/m2，每次最高不超过200mg，一日3次，即每8小时1次；(2)预防母婴传染，怀孕14周以上妇女每次100毫克，每日5次，新生儿出生后12小时，每6小时按每公斤体重2毫克服用6周。

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详细处方信息以本药内容附件PDF文件（200961503465235.pdf）的“原文Priscribing Information”为准
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Retrovir是英国Wellcome药厂生产的抗病毒药,治疗早期人类免疫缺陷病毒 (HIV)疾病有效,每粒胶囊内含Zidovu-dine( 齐多夫定,AZT)100mg和 250mg.一、药理作用Zidovudine在受病毒感染的细胞内被细胞胸腺嘧啶核苷激酶 磷酸化,生成单磷酸醋(MP) 衍生物,再磷酸化生成双磷酸酯(DP).然后分别经由胸腺嘧啶核苷激酶和非特异性激酶转化成活性代谢物三磷酸酯(TP)衍生物Zidovudine-TP.
•RETROVIR, like other HIV medicines, can cause a condition called lactic acidosis and severe liver problems. Lactic acidosis occurs when acid builds up in the blood, which can affect how the body functions. In some cases, lactic acidosis can cause death. Nausea and tiredness that don't get better may be symptoms of lactic acidosis
•Make sure to see your doctor regularly because other serious side effects can occur, such as muscle damage and a decrease in red and/or white blood cells, especially in patients with advanced HIV or AIDS
•Worsening of liver disease (sometimes resulting in death) has occurred in patients infected with both HIV and hepatitis C virus who are taking anti-HIV medicines and are also being treated for hepatitis C with interferon with or without ribavirin. If you are taking RETROVIR as well as interferon with or without ribavirin, and you experience side effects, be sure to tell your doctor
•When you start taking HIV medicines, your immune system may get stronger and may begin to fight infections that have been hidden in your body, such as pneumonia, herpes virus, or tuberculosis. If you have new symptoms after starting your HIV medicines, be sure to tell your doctor
•Changes in body fat may occur in some patients taking antiretroviral therapy. These changes may include an increased amount of fat in the upper back and neck ("buffalo hump"), breast, and around the trunk. Loss of fat from the legs, arms, and face may also occur. The cause and long-term health effects of these conditions are not known at this time
•The most common side effects with RETROVIR were headache, weakness or tiredness, nausea, loss of appetite, and vomiting
•These are not all the side effects you could have when taking this medicine. Your healthcare professional can talk to you about these and other side effects with RETROVIR

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详细处方信息以本药内容附件PDF文件（200961503465235.pdf）的“原文Priscribing Information”为准
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